Role of the Colon in Short Bowel Syndrome and Intestinal Transplantation

被引：50

作者：

Goulet, Olivier ^{[1
]}

Colomb-Jung, Virginie ^{[1
]}

Joly, Francisca ^{[2
]}

机构：

[1] Univ Paris 05, Hop Necker Enfants Malad, Dept Pediat Gastroenterol Hepatol & Nutr, Natl Reference Ctr Rare Digest Dis, F-75015 Paris, France

[2] Univ Paris 06, Hosp Beaujon, Dept Gastroenterol & Nutr, Paris, France

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2009年 / 48卷

关键词：

Colon transplantation; Colonic function; D-Lactic acidosis; Intestinal adaptation; Intestinal microbiota; Medium-chain triglycerides; Noninfectious colitis; Short bowel syndrome; Short-chain fatty acids; TOTAL PARENTERAL-NUTRITION; CHAIN FATTY-ACIDS; ACTING SOMATOSTATIN ANALOG; D-LACTIC ACIDOSIS; ADAPTATION; ABSORPTION; RESECTION; INTERPOSITION; SUPPLEMENTATION; AGANGLIONOSIS;

D O I：

10.1097/MPG.0b013e3181a118ef

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colon is a crucial partner for small intestinal adaptation and function in patients who underwent extensive small intestinal resection or transplantation. This short review deals with the different properties and roles of the colon in these settings, involving fluid and electrolytes absorption, absorption of medium-chain triglycerides, and production of short-chain fatty acids for malabsorbed energy salvage. The colon may adapt after small intestinal resection, whereas it hosts the most important part of the intestinal microbiota, which plays a crucial role in intestinal function and health. Also, colon may be responsible for D-lactic acidosis as well, as it can be injured by noninfectious colitis. Finally, the relevance of a simultaneous colon grafting is discussed as it is occasionally considered in specific patients requiring intestinal transplantation. JPGN 48:S66-S71, 2009.

引用

页码：S66 / S71

页数：6

共 55 条

[1] Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets [J].