Drugs, hERG and sudden death

被引：106

作者：

Brown, AM

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44128 USA

[2] ChanTest Inc, Cleveland, OH 44128 USA

来源：

CELL CALCIUM | 2004年 / 35卷 / 06期

关键词：

screens; throughput; hERG; QT; sudden death;

D O I：

10.1016/j.ceca.2004.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Early recognition of potential QT/TdP liability is now an essential component of the drug discovery/drug development program. The hERG assay is an indispensable step and a high-quality assay must accompany any investigational new drug (IND) application. While it is the gold standard at present, the hERG assay is too labor-intensive and too low throughput to be used as a screen early in the discovery/development process. A variety of indirect high throughput screens have been used. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：543 / 547

页数：5

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