The IKK complex:: an integrator of all signals that activate NF-κB?

被引:341
作者
Israël, A [1 ]
机构
[1] Inst Pasteur, Unite Biol Mol Express Geniq, URA 1773, CNRS, F-75724 Paris 15, France
关键词
D O I
10.1016/S0962-8924(00)01729-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The NF-kappa B family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the cytoplasm, retained by interaction with an inhibitory molecule called I kappa B. Activation of the NF-kappa B signalling cascade results in phosphorylation and degradation of I kappa B, allowing nuclear translocation of the NF-kappa B complexes. The recent identification of a high-molecular-weight complex containing two kinases and a regulatory subunit has led to a flurry of new results that shed light on some of the most complex mechanisms contributing to the exquisite regulation of NF-kappa B activity.
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页码:129 / 133
页数:5
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