共 44 条
The IKK complex:: an integrator of all signals that activate NF-κB?
被引:341
作者:

Israël, A
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Biol Mol Express Geniq, URA 1773, CNRS, F-75724 Paris 15, France Inst Pasteur, Unite Biol Mol Express Geniq, URA 1773, CNRS, F-75724 Paris 15, France
机构:
[1] Inst Pasteur, Unite Biol Mol Express Geniq, URA 1773, CNRS, F-75724 Paris 15, France
关键词:
D O I:
10.1016/S0962-8924(00)01729-3
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The NF-kappa B family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the cytoplasm, retained by interaction with an inhibitory molecule called I kappa B. Activation of the NF-kappa B signalling cascade results in phosphorylation and degradation of I kappa B, allowing nuclear translocation of the NF-kappa B complexes. The recent identification of a high-molecular-weight complex containing two kinases and a regulatory subunit has led to a flurry of new results that shed light on some of the most complex mechanisms contributing to the exquisite regulation of NF-kappa B activity.
引用
收藏
页码:129 / 133
页数:5
相关论文
共 44 条
[1]
Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adaptor proteins that regulates life and death
[J].
Arch, RH
;
Gedrich, RW
;
Thompson, CB
.
GENES & DEVELOPMENT,
1998, 12 (18)
:2821-2830

Arch, RH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA

Gedrich, RW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA

Thompson, CB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA Univ Chicago, Gwen Knapp Ctr Lupus & Immunol Res, Chicago, IL 60637 USA
[2]
The NF-kappa B and I kappa B proteins: New discoveries and insights
[J].
Baldwin, AS
.
ANNUAL REVIEW OF IMMUNOLOGY,
1996, 14
:649-683

Baldwin, AS
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599 UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599
[3]
THE I-KAPPA-B PROTEINS - MULTIFUNCTIONAL REGULATORS OF REL/NF-KAPPA-B TRANSCRIPTION FACTORS
[J].
BEG, AA
;
BALDWIN, AS
.
GENES & DEVELOPMENT,
1993, 7 (11)
:2064-2070

BEG, AA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599

BALDWIN, AS
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599
[4]
Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis
[J].
Bushdid, PB
;
Brantley, DM
;
Yull, FE
;
Blaeuer, GL
;
Hoffman, LH
;
Niswander, L
;
Kerr, LD
.
NATURE,
1998, 392 (6676)
:615-618

Bushdid, PB
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Brantley, DM
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Yull, FE
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Blaeuer, GL
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Hoffman, LH
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Niswander, L
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

Kerr, LD
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA
[5]
IKKγ mediates the interaction of cellular IκB kinases with the tax transforming protein of human T cell leukemia virus type 1
[J].
Chu, ZL
;
Shin, YA
;
Yang, JM
;
DiDonato, JA
;
Ballard, DW
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (22)
:15297-15300

Chu, ZL
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA

Shin, YA
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA

Yang, JM
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA

DiDonato, JA
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA

Ballard, DW
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA
[6]
IKAP is a scaffold protein of the IκB kinase complex
[J].
Cohen, L
;
Henzel, WJ
;
Baeuerle, PA
.
NATURE,
1998, 395 (6699)
:292-296

Cohen, L
论文数: 0 引用数: 0
h-index: 0
机构: Tularik Inc, San Francisco, CA 94080 USA

Henzel, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Tularik Inc, San Francisco, CA 94080 USA

Baeuerle, PA
论文数: 0 引用数: 0
h-index: 0
机构: Tularik Inc, San Francisco, CA 94080 USA
[7]
Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
[J].
Delhase, M
;
Hayakawa, M
;
Chen, Y
;
Karin, M
.
SCIENCE,
1999, 284 (5412)
:309-313

Delhase, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

Hayakawa, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

Chen, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

Karin, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA
[8]
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
[J].
Joseph A. DiDonato
;
Makio Hayakawa
;
David M. Rothwarf
;
Ebrahim Zandi
;
Michael Karin
.
Nature,
1997, 388 (6642)
:548-554

Joseph A. DiDonato
论文数: 0 引用数: 0
h-index: 0
机构:
University of California at San Diego,undefined Laboratory of Gene Regulation and Signal Transduction,Department of Pharmacology

Makio Hayakawa
论文数: 0 引用数: 0
h-index: 0
机构:
Laboratory of Gene Regulation and Signal Transduction,Department of Pharmacology

David M. Rothwarf
论文数: 0 引用数: 0
h-index: 0
机构:
Laboratory of Gene Regulation and Signal Transduction,Department of Pharmacology

Ebrahim Zandi
论文数: 0 引用数: 0
h-index: 0
机构:
Laboratory of Gene Regulation and Signal Transduction,Department of Pharmacology

Michael Karin
论文数: 0 引用数: 0
h-index: 0
机构:
Laboratory of Gene Regulation and Signal Transduction,Department of Pharmacology
[9]
NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses
[J].
Ghosh, S
;
May, MJ
;
Kopp, EB
.
ANNUAL REVIEW OF IMMUNOLOGY,
1998, 16
:225-260

Ghosh, S
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA

May, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA

Kopp, EB
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
[10]
IKKγ serves as a docking subunit of the IκB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
[J].
Harhaj, EW
;
Sun, SC
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (33)
:22911-22914

Harhaj, EW
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

Sun, SC
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA