A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line

被引：87
作者：
Mirakabad, Fatemeh Sadat Tabatabaei [1 ,2 ]
Akbarzadeh, Abolfazl [3 ]
Milani, Morteza [4 ]
Zarghami, Nosratollah [1 ,5 ]
Taheri-Anganeh, Mortaza [1 ]
Zeighamian, Vahideh [1 ]
Badrzadeh, Fariba [1 ]
Rahmati-Yamchi, Mohammad [1 ,5 ]
机构：
[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran
[4] Tabriz Univ Med Sci, Dept Microbiol, Fac Med, Tabriz, Iran
[5] Tabriz Univ Med Sci, Dept Clin Biochem & Lab Sci, Tabriz, Iran
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 01期
关键词：
breast cancer; curcumin; PLGA-PEG; MTT assay; COATED MAGNETIC NANOPARTICLES; IN-VITRO EVALUATION; GENE-EXPRESSION; INHIBITION; DELIVERY; DISEASE;
D O I：
10.3109/21691401.2014.955108
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women worldwide. Herbal medicines have tremendous potential as promising agents for the treatment of cancer. Curcumin is a natural polyphenol which has many anticancer effects. Because of its low aqueous solubility, low bioavailability, and quick degradation and metabolism, curcumin was released using PLGA-PEG nanoparticles. Herein, the efficiency of pure curcumin and curcumin-loaded PLGA-PEG in MCF-7 human breast cancer cell lines was studied. H-1 NMR, FT-IR and SEM demonstrated PLGA-PEG structure and curcumin loaded on nanoparticles. Subsequently, the cytotoxic effects of free curcumin and curcumin-loaded PLGA-PEG were determined via an MTT assay. Our study confirmed that curcumin-loaded PLGA-PEG has more cytotoxic effects on the MCF-7 breast cancer cell line and could be exploited as a potential source for developing novel drugs against breast cancer.
引用
收藏
页码：423 / 430
页数：8
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