What have RNAi screens taught us about viral-host interactions?

被引：43

作者：

Cherry, Sara ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Penn Genome Frontiers Inst, Sch Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 04期

关键词：

C VIRUS-REPLICATION; FUNCTIONAL GENOMIC SCREEN; CELLULAR COFACTORS; HIV-INFECTION; IDENTIFICATION; TRANSLATION;

D O I：

10.1016/j.mib.2009.06.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The blossoming of genomic technologies and miniaturization has opened up the field of genomic scale cell-based screening to the study of viral-host interactions. RNAi technology, while still at its infancy, is being used to identify cellular factors required for various viral infections. This has led to the discovery of hundreds of new factors, and has increased our knowledge of the host factors that impact viral infection and highlighted the cellular pathways at play.

引用

页码：446 / 452

页数：7

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