The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

被引：939

作者：

Bamford, S

Dawson, E

Forbes, S

Clements, J

Pettett, R

Dogan, A

Flanagan, A

Teague, J

Futreal, PA

Stratton, MR

Wooster, R

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[2] Royal Free & Univ Med Sch, Dept Histopathol, London WC1E 6JJ, England

[3] UCL, Inst Orthopaed, Stanmore HA7 4LP, Middx, England

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 02期

基金：

英国惠康基金;

关键词：

somatic; mutation; database; website;

D O I：

10.1038/sj.bjc.6601894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC ( Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

引用

页码：355 / 358

页数：4

共 16 条

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