Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

被引：22

作者：

Gregorova, Michaela ^{[1
]}

Morse, Daniel ^{[1
]}

Brignoli, Tarcisio ^{[1
]}

Steventon, Joseph ^{[1
]}

Hamilton, Fergus ^{[2
]}

Albur, Mahableshwar ^{[2
]}

Arnold, David ^{[2
]}

Thomas, Matthew ^{[2
]}

Halliday, Alice ^{[1
]}

Baum, Holly ^{[1
]}

Rice, Christopher ^{[1
]}

Avison, Matthew B. ^{[1
]}

Davidson, Andrew D. ^{[1
]}

Santopaolo, Marianna ^{[1
]}

Oliver, Elizabeth ^{[1
]}

Goenka, Anu ^{[1
]}

Finn, Adam ^{[1
]}

Wooldridge, Linda ^{[3
]}

Amulic, Borko ^{[1
]}

Boyton, Rosemary J. ^{[4
,5
]}

Altmann, Daniel M. ^{[4
]}

Butler, David K. ^{[4
]}

McMurray, Claire ^{[6
]}

Stockton, Joanna ^{[6
]}

Nicholls, Sam ^{[6
]}

Cooper, Charles ^{[6
]}

Loman, Nicholas ^{[6
]}

Cox, Michael J. ^{[5
]}

Rivino, Laura ^{[1
]}

Massey, Ruth C. ^{[1
]}

机构：

[1] Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England

[2] North Bristol NHS Trust, Bristol, Avon, England

[3] Bristol Vet Sch, Fac Hlth Sci, Bristol, Avon, England

[4] Imperial Coll London, Dept Infect Dis, London, England

[5] Royal Brompton & Harefield NHS Fdn Trust, Lung Div, London, England

[6] Univ Birmingham, Inst Microbiol & Infect, Birmingham, W Midlands, England

来源：

ELIFE | 2020年 / 9卷

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会; 英国科研创新办公室;

关键词：

MICROBIAL COMMUNITY; DNA;

D O I：

10.7554/eLife.63430

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.

引用

页码：1 / 13

页数：13

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