Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

被引：265

作者：

Xuan, Mingjun ^{[1
,2
]}

Shao, Jingxin ^{[1
,2
]}

Zhao, Jie ^{[1
]}

Li, Qi ^{[1
,3
]}

Dai, Luru ^{[2
]}

Li, Junbai ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Inst Chem, Beiyijie 2, Beijing 100190, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beiyitiao 11, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 21期

基金：

中国国家自然科学基金;

关键词：

magnetic nanoparticles; mesoporous silica; photodynamic therapy; red blood cell membrane; singlet oxygen; ERYTHROCYTE-MEMBRANE; BIOMIMETIC NANOPARTICLES; POLYMERIC NANOPARTICLES; PHOTODYNAMIC THERAPY; GOLD NANOCAGES; DRUG-DELIVERY; NANOCARRIERS;

D O I：

10.1002/anie.201712996

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. Magnetic mesoporous silica nanoparticles (MMSNs) were cloaked with red blood cell membrane (RBC). This integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. Invivo experiments demonstrate that RBC@MMSNs can avoid immune clearance and achieve magnetic field (MF)-induced high accumulation in a tumor. When light irradiation is applied, singlet oxygen rapidly generates from hypocrellinB (HB)-loaded RBC@MMSN and leads to the necrosis of tumor tissue. Such a RBC-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, MF-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy.

引用

页码：6049 / 6053

页数：5

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