Prediction of necessity for coronary artery revascularization by adenosine contrast-enhanced magnetic resonance imaging

Background: Assessing myocardial first-pass wash-in during pharmacological induced stress allows detection of perfusion deficits and indicates stenotic coronary arteries (CA). The aim of our study was to demonstrate clinical relevance of contrast-enhanced stress magnetic resonance imaging (CMR) by predicting necessity of CA intervention. Methods: 738 patients with scheduled coronary angiography (CXA) were scanned in a 1.5 Tesla CMR scanner. After 3 min of adenosine infusion (140 mu g/kg/min), first-pass kinetic of contrast agent was evaluated. Myocardial necrosis was visualized with "myocardial late enhancement (MLE)". Perfusion deficits were described as either "ischemia in viable myocardium", or "no relevant ischemia in viable myocardium" or as "ischemia in chronic myocardial infarction (CMI)" based on spatial and temporal extent of ischemia and of MLE. CXA was performed in all patients within 48 It after CMR and revascularization, if applicable, was performed. Angiograms were read by two independent and blinded investigators and matched with CMR findings. Results: 539 patients (73%) showed "ischemia in viable myocardium" and revascularization was performed in 513 patients (95%). In I I I patients with "no relevant ischemia in viable myocardium", revascularization was performed in only 5 patients (5%). In 88 patients classified as "ischemia in CMI", revascularization was performed in 14 patients (16%). Positive predictive value of CMR for CA intervention was 0.95, negative predictive value was 0.89, sensitivity was 0.96, and specificity was 0.87. Conclusion: CMR allows clinical useful prediction of relevant CA disease with need for revascularization prior to CXA and may be used as non-invasive test for myocardial ischemia and viability to guide further therapy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.