The Hedgehog response network: Sensors, switches, and routers

被引：674

作者：

Lum, L ^{[1
]}

Beachy, PA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

SCIENCE | 2004年 / 304卷 / 5678期

关键词：

D O I：

10.1126/science.1098020

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homeostasis and pathological roles in tumor initiation and growth. Recent advances in our understanding of Hh response have resulted from the identification of new pathway components and new mechanisms of action for old pathway components. The most striking new finding is that signal transmission from membrane to cytoplasm proceeds through recruitment, by the seven-transmembrane protein Smoothened, of an atypical kinesin, which routes pathway activation by interaction with other components of a complex that includes the latent zinc finger transcription factor, Ci.

引用

页码：1755 / 1759

页数：5

共 66 条

[21] Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail [J].