A pyrazolo[1,5-a]pyridine-based ratiometric fluorescent probe for sensing Cu2+ in cell

被引：19
|
作者：
Duan, Guiyun [1 ]
Zhang, Gongxiao [1 ]
Yuan, Shuqing [2 ]
Ji, Ruixue [1 ]
Zhang, Litao [3 ]
Ge, Yanqing [1 ]
机构：
[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Chem & Pharmaceut Engn, Tai An 271016, Shandong, Peoples R China
[2] First Peoples Hosp Jinan, Jinan 250011, Shandong, Peoples R China
[3] Taian Cent Hosp, Dept Imaging, Tai An 271000, Shandong, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2019年 / 219卷
关键词：
Pyrazolo[1,5-a]pyridine; Cu2+; FRET; Bioimaging; RHODAMINE FRET SYSTEM; OPTICAL-PROPERTIES; HG2+; FLUOROPHORE; INDOLIZINE; PH; CHEMOSENSOR; PLATFORM; DESIGN; CU(II);
D O I：
10.1016/j.saa.2019.04.057
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Ratiometric fluorescent probes based on FRET mechanism have attracted great attention due to their large pseudo-Stokes shifts and built-in correction for environmental effects. However, most donors failed to meet the requirement that the emission of the donor must overlap well with the absorption of the acceptor. Therefore, searching for new fluorophore to construct FRET system is in great need. In this paper, a new fluorescent dye pyrazolo[1,5-a]pyridine was synthesized and used as a donor in the FRET system for raliometric sensing of Cu2+. The probe is based on FRET and PET mechanism. It shows high selectivity and sensitivity toward Cu2+ (detection limit 30 nM). Furthermore, it was successfully used to detect Cu2+ in Glioma cells. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：173 / 178
页数：6
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