Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety

被引：158

作者：

Kang, YK

Shin, KJ

Yoo, KH

Seo, KJ

Hong, CY

Lee, CS

Park, SY

Kim, DJ

Park, SW ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea

[2] LG Chem Ltd, Biotech Res Inst, Daejeon 305380, South Korea

[3] Korea Res Inst Chem Technol, Daejeon, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(99)00646-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of a series of new 1 beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-1 comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-1, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：95 / 99

页数：5

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