Emerging biomarker in carcinogenesis. Focus on Nestin

被引：4

作者：

Nowogrodzka, Katarzyna ^{[1
]}

Jankowska-Konsur, Alina ^{[1
,2
]}

机构：

[1] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Dermatol Venerol & Allergol, 1 Chalubinskiego St, PL-50368 Wroclaw, Poland

来源：

POSTEPY DERMATOLOGII I ALERGOLOGII | 2022年 / 39卷 / 06期

关键词：

nestin; carcinogenesis; angiogenesis; basal cell carcinoma; squamous cell carcinoma; melanoma; cancer; STEM-CELL MARKERS; INTERMEDIATE-FILAMENT NESTIN; OUTER ROOT SHEATH; DERMATOFIBROSARCOMA PROTUBERANS; EXPRESSION; CARCINOMA; TUMOR; CANCER; CD133; GROWTH;

D O I：

10.5114/ada.2022.122599

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Nestin is a protein belonging to class VI intermediate filaments, which is involved in organogenesis, cellular me- tabolism and cytoskeletal organisation. Originally found to be expressed in neuroepithelial stem cells, nestin is also expressed in other tissues. It plays an important role in the carcinogenesis and angiogenesis. Its increased expression in melanoma is associated with an aggressive course of the disease and poor prognosis. Research findings for non-melanocytic skin neoplasms are inconclusive. The aim of this paper was to systematize knowledge on the role of nestin in cancerogenesis. The authors focused in particular on the expression of nestin in skin malignancies, as well as on the potential role of nestin in the pathogenesis, prognosis and treatment of cutaneous neoplasms.

引用

页码：1001 / 1007

页数：7

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