THE DESIGN AND SYNTHESIS OF SMALL SUBSTANCE P (1-7) MIMETICS BASED ON SUBSTITUTED HETEROAROMATIC SCAFFOLDS

被引:0
|
作者
Fransson, R. [1 ]
Botros, M. [2 ]
Skold, C. [1 ]
Nyberg, F. [2 ]
Hallberg, M. [2 ]
Sandstrom, A. [1 ]
机构
[1] Uppsala Univ, Dept Med Chem, SE-75123 Uppsala, Sweden
[2] Uppsala Univ, Dept Pharmaceut Biosci, SE-75124 Uppsala, Sweden
关键词
SPINAL-CORD; BINDING;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:345 / 345
页数:1
相关论文
共 15 条
  • [11] Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists
    Ismail, Mohamed A. H.
    Aboul-Enein, Mohamed Nabil
    El-Azzouny, Aida Abd ElSatar
    Abouzid, Khaled A. M.
    Ismail, Nasser S. M.
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) : 442 - 458
  • [12] Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid
    Singh, Satyakam
    Prasad, Nagarajan Rajendra
    Chufan, Eduardo E.
    Patel, Bhargav A.
    Wang, Yi-Jun
    Chen, Zhe-Sheng
    Ambudkar, Suresh V.
    Talele, Tanaji T.
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (10) : 4058 - 4072
  • [13] Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist
    Courter, Joel R.
    Madani, Navid
    Sodroski, Joseph
    Schoen, Arne
    Freire, Ernesto
    Kwong, Peter D.
    Hendrickson, Wayne A.
    Chaiken, Irwin M.
    LaLonde, Judith M.
    Smith, Amos B., III
    ACCOUNTS OF CHEMICAL RESEARCH, 2014, 47 (04) : 1228 - 1237
  • [14] Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran Derivatives as P2 Ligands
    Ghosh, Arun K.
    Kovela, Satish
    Sharma, Ashish
    Shahabi, Dana
    Ghosh, Ajay K.
    Hopkins, Denver R.
    Yadav, Monika
    Johnson, Megan E.
    Agniswamy, Johnson
    Wang, Yuan-Fang
    Hattori, Shin-Ichiro
    Higashi-Kuwata, Nobuyo
    Aoki, Manabu
    Amano, Masayuki
    Weber, Irene T.
    Mitsuya, Hiroaki
    CHEMMEDCHEM, 2022, 17 (09)
  • [15] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies
    Ghosh, Arun K.
    Kovela, Satish
    Osswald, Heather L.
    Amano, Masayuki
    Aoki, Manabu
    Agniswamy, Johnson
    Wang, Yuan-Fang
    Weber, Irene T.
    Mitsuya, Hiroaki
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (09) : 4867 - 4879