Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection

被引：2

作者：

Glazkova, D. V. ^{[1
,2
]}

Urusov, F. A. ^{[1
,2
]}

Bogoslovskaya, E. V. ^{[1
]}

Shipulin, G. A. ^{[1
]}

机构：

[1] Fed Med Biol Agcy Russian Federat, Ctr Strateg Planning & Management Med & Biol Hlth, Moscow 119992, Russia

[2] Izmerov Res Inst Occupat Hlth, Moscow 105275, Russia

来源：

MOLECULAR BIOLOGY | 2020年 / 54卷 / 05期

关键词：

TRIM5; alpha; HIV-1; gene therapy; REVERSE TRANSCRIPTION; CYTOPLASMIC BODIES; SPRY DOMAIN; T-CELLS; PROTEIN; INHIBITION; INTERMEDIATE; DEGRADATION; COMBINATION; RECOGNITION;

D O I：

10.1134/S0026893320050039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is commonly known that the antiviral activity of the TRIM5 alpha protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5 alpha can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5 alpha protein and the prospects for using it in gene therapy of HIV infection.

引用

页码：623 / 632

页数：10

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