Synthesis of Optically Active 2-Amino-1,3,4-oxadiazoles and their Hybrid Peptides

被引：4

作者：

Madhu, Chilakapati ^{[1
]}

Prabhu, Girish ^{[1
]}

Pal, Rumpa ^{[2
]}

Row, T. N. Guru ^{[2
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

[2] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 05期

关键词：

CONVENIENT SYNTHESIS; BUILDING-BLOCKS; AMINO-ACIDS; UGI-MCR; PEPTIDOMIMETICS; DESIGN; OXADIAZOLES; ANALOGS; RING;

D O I：

10.1002/jhet.2166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 2-amino-1,3,4-oxadiazole derivatives of N-Cbz(benzyloxycarbonyl)/Boc-protected amino/peptide acids under sonication is described. The conditions involved in the present protocol are simple, mild, and racemization free. The utility of 2-amino group in the substituted oxadiazoles for the incorporation of peptide and ureido bonds to obtain hybrid peptidomimetics is also delineated. The 2-amino-1,3,4-oxadiazole 3b was obtained as a single crystal, and its molecular structure has been confirmed through X-ray crystallographic study.

引用

页码：1438 / 1446

页数：9

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