A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake

被引：33
作者：
Cheng, Tangjian [1 ]
Ma, Rujiang [1 ]
Zhang, Yumin [2 ,3 ]
Ding, Yuxun [1 ]
Liu, Jinjian [2 ,3 ]
Ou, Hanlin [1 ]
An, Yingli [1 ]
Liu, Jianfeng [2 ,3 ]
Shi, Linqi [1 ]
机构：
[1] Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Minist Educ,Inst Polymer Chem,Key Lab Funct Polym, Tianjin 300071, Peoples R China
[2] Chinese Acad Med Sci, Tianjin Key Lab Radiat Med & Mol Nucl Med, Inst Radiat Med, Tianjin 300192, Peoples R China
[3] Peking Union Med Coll, Tianjin 300192, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 81期
基金：
中国国家自然科学基金;
关键词：
ANTICANCER DRUG-DELIVERY; NONVIRAL GENE DELIVERY; POLYMERIC MICELLES; GOLD NANOPARTICLES; PROTEIN ADSORPTION; TUMOR; PH; CHARGE; EFFICACY; THERAPY;
D O I：
10.1039/c5cc05854f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on the protonation/deprotonation of poly(beta-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).
引用
收藏
页码：14985 / 14988
页数：4
相关论文
共 32 条
[1]   LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].
ALLEN, TM ;
HANSEN, C ;
MARTIN, F ;
REDEMANN, C ;
YAUYOUNG, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1066 (01) :29-36
[2]  
[Anonymous], 2012, ANGEW CHEM INT EDIT
[3]   Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles [J].
Arvizo, Rochelle R. ;
Miranda, Oscar R. ;
Moyano, Daniel F. ;
Walden, Chad A. ;
Giri, Karuna ;
Bhattacharya, Resham ;
Robertson, J. David ;
Rotello, Vincent M. ;
Reid, Joel M. ;
Mukherjee, Priyabrata .
PLOS ONE, 2011, 6 (09)
[4]   Effect of Nanoparticle Surface Charge at the Plasma Membrane and Beyond [J].
Arvizo, Rochelle R. ;
Miranda, Oscar R. ;
Thompson, Michael A. ;
Pabelick, Christina M. ;
Bhattacharya, Resham ;
Robertson, J. David ;
Rotello, Vincent M. ;
Prakash, Y. S. ;
Mukherjee, Priyabrata .
NANO LETTERS, 2010, 10 (07) :2543-2548
[5]   Targeted drug delivery to tumors: Myths, reality and possibility [J].
Bae, You Han ;
Park, Kinam .
JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) :198-205
[6]   Random Copolymer Films with Molecular-Scale Compositional Heterogeneities that Interfere with Protein Adsorption [J].
Baxamusa, Salmaan H. ;
Gleason, Karen K. .
ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (21) :3489-3496
[7]   Zwitterionic Biocompatible Quantum Dots for Wide pH Stability and Weak Nonspecific Binding to Cells [J].
Breus, Vladimir V. ;
Heyes, Colin D. ;
Tron, Kyrylo ;
Nienhaus, G. Ulrich .
ACS NANO, 2009, 3 (09) :2573-2580
[8]   Understanding the Role of Surface Charges in Cellular Adsorption versus Internalization by Selectively Removing Gold Nanoparticles on the Cell Surface with a I2/KI Etchant [J].
Cho, Eun Chul ;
Xie, Jingwei ;
Wurm, Patricia A. ;
Xia, Younan .
NANO LETTERS, 2009, 9 (03) :1080-1084
[9]   Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects [J].
Deng, Chao ;
Jiang, Yanjiao ;
Cheng, Ru ;
Meng, Fenghua ;
Zhong, Zhiyuan .
NANO TODAY, 2012, 7 (05) :467-480
[10]   The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes [J].
Deshpande, MC ;
Davies, MC ;
Garnett, MC ;
Williams, PM ;
Armitage, D ;
Bailey, L ;
Vamvakaki, M ;
Armes, SP ;
Stolnik, S .
JOURNAL OF CONTROLLED RELEASE, 2004, 97 (01) :143-156
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