Oxidative stress involvement in Physalis angulata-induced apoptosis in human oral cancer cells

被引：50

作者：

Lee, H. -Z. ^{[1
]}

Liu, W. -Z. ^{[1
]}

Hsieh, W. -T. ^{[2
]}

Tang, F. -Y. ^{[3
]}

Chung, J. -G. ^{[4
]}

Leung, Henry W. -C. ^{[5
]}

机构：

[1] China Med Univ, Sch Pharm, Taichung 40402, Taiwan

[2] China Med Univ, Dept Pharmacol, Taichung, Taiwan

[3] China Med Univ, Dept Nutr, Taichung, Taiwan

[4] China Med Univ, Dept Microbiol, Taichung, Taiwan

[5] Chi Mei Hosp, Dept Radiat Oncol, Tainan, Taiwan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 03期

关键词：

Physalis angulata; HSC-3 oral cancer cells; Apoptosis; Oxidative stress; Reactive oxygen species; Heme oxygenase-1; ENDOPLASMIC-RETICULUM STRESS; HEME OXYGENASE-1; REDOX REGULATION; UP-REGULATION; PC12; CELLS; ER STRESS; DEATH; ROS; EXPRESSION; MITOCHONDRIAL;

D O I：

10.1016/j.fct.2008.12.013

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this report, we investigated the role of oxidative stress in Physalis angulata-induced apoptosis of human oral cancer cells. P. angulata-induced apoptosis was characterized by nuclear morphological changes, membrane blebbing and activation of caspase-9. Exposure of HSC-3 cells to P. angulata caused production of reactive oxygen species and up-regulation of oxidative stress markers heme oxygenase-1 (HO-1), Superoxide dismutase (SOD), heat shock protein 70 (HSP70) and caspase-4. Down-regulation of HO-1, SOD and HSP70 proteins expression by attenuation of oxidative stress, pretreatment with glutathione or N-acetylcysteine, significantly decreased P. angulata-triggered cell death. The present study also demonstrated that the mitochondria and the endoplasmic reticulum are the targets of P. angulata in HSC-3 cells. Our results revealed that: (1) reactive oxygen species may play a dominant role in this process, (2) A angulata induces oxidative stress in HSC-3 cells, (3) P. angulata-initiated apoptosis is caused through oxidative stress-dependent induction of heme oxygenase-1, Cu/Zn SOD and HSP70 proteins expression and (4) antioxidants inhibited P. angulata-induced cell death through inhibition of the proteins expression of HO-1, Cu/Zn SOD and HSP70. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：561 / 570

页数：10

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