Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

被引：150

作者：

Ge, Peng ^{[1
,2
]}

Luo, Yalan ^{[1
,2
]}

Okoye, Chukwuemeka Samuel ^{[3
]}

Chen, Haiyang ^{[1
,2
]}

Liu, Jiayue ^{[1
,2
]}

Zhang, Guixin ^{[1
,2
]}

Xu, Caiming ^{[1
,2
]}

Chen, Hailong ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Dept Gen Surg, Affiliated Hosp 1, Dalian 116011, Peoples R China

[2] Dalian Med Univ, Inst Coll Integrat Med, Dalian 116044, Peoples R China

[3] Dalian Univ, Orthoped Res Ctr, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 132卷

基金：

中国国家自然科学基金;

关键词：

Severe acute pancreatitis; Lung injury; Systemic inflammatory response syndrome; Intestinal barrier; Pathogen-associated molecular patterns; Damage-associated molecular patterns; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; GUT BARRIER; NECROTIZING PANCREATITIS; MESENTERIC LYMPH; DOWN-REGULATION; TISSUE-DAMAGE; ACINAR-CELLS; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS;

D O I：

10.1016/j.biopha.2020.110770

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS). Acute lung injury (ALI) is one of the most serious complications of SAP. However, the specific pathogenesis of SAP-associated ALI is not fully understood. Crosstalk and multi-mechanisms involving pancreatic necrosis, bacteremia, intestinal barrier failure, activation of inflammatory cascades and diffuse alveolar damage is the main reason for the unclear pathological mechanism of SAP-associated ALI. According to previous research on SAP-associated ALI in our laboratory and theories put forward by other scholars, we propose that the complex pattern of SAP-associated ALI is based on the "pancreas-intestine-inflammation/endotoxin-lung (P-I-I/E-L) pathway". In this review, we mainly concentrated on the specific details of the "P-I-I/E-L pathway" and the potential treatments or preventive measures for SAP-associated ALI.

引用

页数：13

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