Antioxidant effects of Genkwa flos flavonoids on Freund's adjuvant-induced rheumatoid arthritis in rats

被引：51

作者：

Zhang, Chun-Feng ^{[1
,2
,3
]}

Zhang, Su-Li ^{[1
]}

He, Xin ^{[4
]}

Yang, Xiao-Lin ^{[5
]}

Wu, Hai-Tao ^{[1
]}

Lin, Fiao-Qin ^{[6
]}

Jiang, Cui-Ping ^{[1
]}

Wang, Jun ^{[1
]}

Yu, Chun-Hao ^{[2
,3
]}

Yang, Zhong-Lin ^{[1
]}

Wang, Chong-Zhi ^{[2
,3
]}

Li, Ping ^{[1
]}

Yuan, Chun-Su ^{[2
,3
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] Univ Chicago, Tang Ctr Herbal Med, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA

[4] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210000, Jiangsu, Peoples R China

[5] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[6] Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2014年 / 153卷 / 03期

关键词：

Genkwa flos; Flavonoid aglycone; Rheumatoid arthritis; Antioxidant; Hemorheology; WHOLE-BLOOD VISCOSITY; DAPHNE-GENKWA; LUTEOLIN; INFLAMMATION; EXPRESSION; EXTRACT;

D O I：

10.1016/j.jep.2014.03.046

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethnopharmacological relevance: Genkwa flos (Daphne genkwa Sieb. et Zucc.), a Chinese herbal medicine, has been traditionally used for over two thousand years in China for inflammation related symptoms, including joint pain. To evaluate the antioxidative effects of flavonoid aglycones (FA) isolated from Genkwa flos on adjuvant arthritis in rats and to identify the relationship between antioxidant potential and whole blood viscosity (WBV). Materials and methods: FA compounds were identified using LC-MS and the content was assayed by HPLC. Arthritis was induced by an intradermal injection of Freund's complete adjuvant in the footpad. The effects of FA on paw volumes, secondary arthritis scores, histopathology of joints, and body and organ weights were measured. The antioxidant effects of FA and WBV were determined. Results: LC-MS analysis showed that the FA contained four major compounds: luteolin, apigenin, hydroxygenlcwanin and genkwanin. FA significantly decreased paw edema, arthritis scores, and weight loss. These observations were consistent with the reduction of oxidative stress and the improvement of the WBV. Conclusion: FA significantly decreased arthritis in a rat model through antioxidant and hemorheological modulatory mechanisms. The Genkwa flos flavonoids may have clinical potential for the treatment of rheumatoid arthritis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：793 / 800

页数：8

共 34 条

[1] Anti-arthritic and antioxidant activity of leaves of Alstonia scholaris Linn. R.Br. [J].

Arulmozhi, Sinnathambi ;

Mazumder, Papiya Mitra ;

Sathiyanarayanan, Lohidasan ;

Ashok, Purnima .

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 2011, 3 (02) :E83-E90

[2]

BALABANOVA R M, 1990, Revmatologiya, P36

[3] Daphne Genkwa Sieb. et Zucc. Water-Soluble Extracts Act on Enterovirus 71 by Inhibiting Viral Entry [J].

Chang, Chia-Wen ;

Leu, Yan-Lii ;

Horng, Jim-Tong .

VIRUSES-BASEL, 2012, 4 (04) :539-556

[4] Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages [J].

Chen, Chiu-Yuan ;

Peng, Wen-Huang ;

Tsai, Kuen-Daw ;

Hsu, Shih-Lan .

LIFE SCIENCES, 2007, 81 (23-24) :1602-1614

[5] The New Use of an Ancient Remedy: A Double-Blinded Randomized Study on the Treatment of Rheumatoid Arthritis [J].

Chen, Letian ;

Qi, Haiyu ;

Jiang, Dezhen ;

Wang, Renshuo ;

Chen, Aidong ;

Yan, Zhixiang ;

Xiao, Jun .

AMERICAN JOURNAL OF CHINESE MEDICINE, 2013, 41 (02) :263-280

[6] Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats [J].

Fan, AY ;

Lao, L ;

Zhang, RX ;

Zhou, AN ;

Wang, LB ;

Moudgil, KD ;

Lee, DYW ;

Ma, ZZ ;

Zhang, WY ;

Berman, BM .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 101 (1-3) :104-109

[7]

[高晓雯 GAO Xiaowen], 2006, [中草药, Chinese Traditional and Herbal Drugs], V37, P721

[8]

Hadjigogos K, 2003, PANMINERVA MED, V45, P7

[9] Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells [J].

Kang, Hee-Kap ;

Ecklund, Diane ;

Liu, Michael ;

Datta, Syamal K. .

ARTHRITIS RESEARCH & THERAPY, 2009, 11 (02)

[10] Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant [J].

Lam, Francis Fu Yuen ;

Ko, Iris Wai Man ;

Ng, Ethel Sau Kuen ;

Tam, Lai Shan ;

Leung, Ping Chung ;

Li, Edmund Kwok Ming .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 120 (01) :44-50

← 1 2 3 4 →