Solubility and thermodynamic properties of nimodipine in pure and binary solvents at a series of temperatures

被引：35

作者：

Yu, Shuai ^{[1
,2
]}

Xing, Wenguo ^{[4
]}

Xue, Fumin ^{[1
,2
]}

Cheng, Yan ^{[1
,2
]}

Li, Bing ^{[3
]}

机构：

[1] Qilu Univ Technol, Sch Pharmaceut Sci, Shandong Acad Sci, Jinan 250014, Peoples R China

[2] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Peoples R China

[3] Qilu Univ Technol, Adv Mat Inst, Shandong Prov Key Lab Special Silicon Containing, Shandong Acad Sci, Jinan 250014, Peoples R China

[4] Qingdao Univ Sci & Technol, Chem Technol Res Inst Shandong, Jinan 250014, Peoples R China

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2021年 / 152卷

基金：

中国国家自然科学基金;

关键词：

Solubility; Nimodipine; Thermodynamic model; Dissolution properties; Pure and binary solvents; DISSOLUTION ENHANCEMENT; LIQUID-EQUILIBRIUM; WATER; EXPRESSION; MIXTURES; ENERGY;

D O I：

10.1016/j.jct.2020.106259

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubilities of nimodipine in pure solvents (i.e., methanol, ethanol, n-propanol, i-propanol, n-butanol, i-butanol, s-butanol, n-pentanol, i-pentanol, acetone, cyclohexanone, acetonitrile, tetrahydrofuran, ethyl formate, methyl acetate, and ethyl acetate) and binary solvent mixtures (methanol + water) was determined using a gravimetric method over a temperature range from 278.15 K to 318.15 K at atmospheric pressure. The solubility data in the single solvents were fitted by the modified Apelblat equation, lambda h equation, NRTL equation, and Wilson equation, while the solubility data in binary solvent mixtures were correlated by the CNIBS/R-K equation, modified Jouyban-Acree equation, NRTL equation, and Wilson equation. The relative average deviation (RAD), and root mean square deviation (RMSD) were chosen to evaluate the fitting degree of each model. The dissolution enthalpy, entropy, and Gibbs energy changes of nimodipine were evaluated by the Wilson model. The solubility data, thermodynamic parameters and dissolution properties for nimodipine will provide significant guidance for the optimization of the crystallization process in industry. (C) 2020 Elsevier Ltd.

引用

页数：15

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