Expression of testicular genes in haematological malignancies

被引：42

作者：

Lim, SH ^{[1
]}

Austin, S ^{[1
]}

Owen-Jones, E ^{[1
]}

Robinson, L ^{[1
]}

机构：

[1] Univ Wales, Coll Med, Dept Haematol, Cardiff, S Glam, Wales

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 81卷 / 07期

关键词：

CT antigens; leukaemia; myeloma;

D O I：

10.1038/sj.bjc.6690824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gene expression of a new group of tumour antigens known as cancer/testis (CT) antigens is now well-recognized in some solid tumours. However, their expression in haematological malignancies remained unclear. In this study, we have used reverse transcription polymerase chain reaction and Southern blot analysis to examine the presence of transcripts for the three CT antigens, NY-ESO-1, SSX2 and SCP1 in haematological malignant cells. We found that transcripts for SCP1 could be detected in 10% of myeloma, 5.7% of acute myeloid leukaemia and 23% of chronic myeloid leukaemia. In contrast, NY-ESO-1 and SSX2 were not detected in any of the 107 tumour samples. (C) 1999 Cancer Research Campaign.

引用

页码：1162 / 1164

页数：3

共 18 条

[1] A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening [J].

Chen, YT ;

Scanlan, MJ ;

Sahin, U ;

Tureci, O ;

Gure, AO ;

Tsang, SL ;

Williamson, B ;

Stockert, E ;

Pfreundschuh, M ;

Old, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1914-1918

[2] Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia [J].

Choudhury, A ;

Gajewski, JL ;

Liang, JC ;

Popat, U ;

Claxton, DF ;

Kliche, KO ;

Andreeff, M ;

Champlin, RE .

BLOOD, 1997, 89 (04) :1133-1142

[3] Cytokine enhancement of immunogenicity in chronic myeloid leukaemia [J].

Coleman, S ;

Throp, D ;

Fisher, J ;

Bailey-Wood, R ;

Lim, SH .

LEUKEMIA, 1997, 11 (12) :2055-2059

[4]

Gure AO, 1997, INT J CANCER, V72, P965, DOI 10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO

[5]

2-N

[6] INDUCTION OF IMMUNE-RESPONSES IN PATIENTS WITH B-CELL LYMPHOMA AGAINST THE SURFACE-IMMUNOGLOBULIN IDIOTYPE EXPRESSED BY THEIR TUMORS [J].

KWAK, LW ;

CAMPBELL, MJ ;

CZERWINSKI, DK ;

HART, S ;

MILLER, RA ;

LEVY, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (17) :1209-1215

[7] In vitro cytokine-primed leukaemia cells induce in vivo T cell responsiveness in chronic myeloid leukaemia [J].

Lim, SH ;

Coleman, S ;

Bailey-Wood, R .

BONE MARROW TRANSPLANTATION, 1998, 22 (12) :1185-1190

[8]

LIM SH, 1999, IN PRESS INT J CANC

[9] New paths in human cancer serology [J].

Old, LJ ;

Chen, YT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1163-1167

[10] BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors [J].

Pawelec, G ;

Max, H ;

Halder, T ;

Bruserud, O ;

Merl, A ;

daSilva, P ;

Kalbacher, H .

BLOOD, 1996, 88 (06) :2118-2124

← 1 2 →