Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma

被引:43
作者
Choi, Ji Hye [1 ]
Cho, Young-Seok [2 ]
Ko, Yoon Ho [2 ]
Hong, Soon Uk [3 ]
Park, Jin Hee [1 ]
Lee, Myung Ah [4 ]
机构
[1] Catholic Univ Korea, Coll Med, Dept Biomed Sci, Seoul 137701, South Korea
[2] Catholic Univ Korea, Coll Med, Uijeongbu St Marys Hosp, Dept Internal Med, Uijongbu 480717, South Korea
[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea
[4] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Internal Med, Seoul 137701, South Korea
基金
新加坡国家研究基金会;
关键词
CANCER CELLS; BECLIN; TUMORIGENESIS; PATTERNS; LC3; INHIBITION; IMPACT;
D O I
10.1155/2014/179586
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aim. Autophagy, a cellular degradation process, has paradoxical roles in tumorigenesis and the progression of human cancers. The aim of this study was to investigate the expression levels of autophagy-related proteins in colorectal cancer (CRC) and to evaluate their prognostic significance. Methods. This study is a retrospective review of immunohistochemical and clinicopathological data. All specimens evaluated were obtained from 263 patients with colorectal cancer who had undergone surgery between November 1996 and August 2007. The primary outcomes measured were the expression levels of three autophagy-related proteins (ATG5, BECN1/Beclin 1, and Microtubule-associated protein 1 light chain 3B (LC3B)) by immunohistochemistry and its association in clinicopathological parameters and patient survival. Results. The autophagy-related protein expression frequencies were 65.1% (151/232) for ATG5, 71.3% (174/244) for BECN1, and 74.7% (186/249) for LC3B for the 263 patients. Correlation between the expression of autophagy-related proteins was significant for all protein pairs. Multivariate analysis showed that negative LC3B expression and absence of autophagy-related proteins expression were independently associated with poor prognosis. Conclusion. Absence of autophagy-related proteins expression is associated with poor clinical outcome in CRC, suggesting that these proteins have potential uses as novel prognostic markers.
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页数:10
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