Cellular and humoral biomarkers of Bronchopulmonary Dysplasia

被引：19

作者：

Lal, Charitharth Vivek ^{[1
]}

Ambalavanan, Namasivayam ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat, Div Neonatol, Women & Infants Ctr, 176F Suite 9380,619 South 19th St, Birmingham, AL 35249 USA

来源：

EARLY HUMAN DEVELOPMENT | 2017年 / 105卷

关键词：

Bronchopulmonary Dysplasia; Pulmonary hypertension; Microbiome; Biomarkers; Systems biology; BIRTH-WEIGHT INFANTS; EXPOSED NEWBORN RATS; CHRONIC LUNG-DISEASE; PRETERM INFANTS; AIRWAY MICROBIOME; SYSTEMS BIOLOGY; T-CELLS; IDENTIFICATION; INFLAMMATION; SUSCEPTIBILITY;

D O I：

10.1016/j.earlhumdev.2016.12.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The pathogenesis of Bronchopulmonary Dysplasia (BPD) is multifactorial and the clinical phenotype of BPD is extremely variable. Predicting BPD is difficult, as it is a disease with a clinical operational definition but many clinical phenotypes and endotypes. Most biomarkers studied over the years have low predictive accuracy, and none are currently used in routine clinical care or shown to be useful for predicting longer-term respiratory outcome. Targeted cellular and humoral biomarkers and novel systems biology 'omic' based approaches including genomic and microbiomic analyses are described in this review. (C) 2016 Published by Elsevier Ireland Ltd.

引用

页码：35 / 39

页数：5

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