Nanoparticle-based Cell Trackers for Biomedical Applications

被引：50

作者：

Ni, Jen-Shyang ^{[1
,2
]}

Li, Yaxi ^{[1
,3
]}

Yue, Wentong ^{[1
]}

Liu, Bin ^{[4
]}

Li, Kai ^{[1
]}

机构：

[1] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

[2] HKUST Shenzhen Res Inst, Shenzhen 518057, Peoples R China

[3] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

[4] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore, Singapore

来源：

THERANOSTICS | 2020年 / 10卷 / 04期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; bioimaging; cell tracking; semiconducting polymer; therapy; AGGREGATION-INDUCED EMISSION; IRON-OXIDE NANOPARTICLES; MESENCHYMAL STEM-CELLS; LONG-TERM TRACKING; AG2S QUANTUM DOTS; IN-VIVO TRACKING; GUIDED PHOTODYNAMIC THERAPY; SEMICONDUCTING POLYMER; PHOTOTHERMAL THERAPY; ORGANIC NANOPARTICLES;

D O I：

10.7150/thno.39915

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The continuous or real-time tracking of biological processes using biocompatible contrast agents over a certain period of time is vital for precise diagnosis and treatment, such as monitoring tissue regeneration after stem cell transplantation, understanding the genesis, development, invasion and metastasis of cancer and so on. The rationally designed nanoparticles, including aggregation-induced emission (AIE) dots, inorganic quantum dots (QDs), nanodiamonds, superparamagnetic iron oxide nanoparticles (SPIONs), and semiconducting polymer nanoparticles (SPNs), have been explored to meet this urgent need. In this review, the development and application of these nanoparticle-based cell trackers for a variety of imaging technologies, including fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, magnetic particle imaging, positron emission tomography and single photon emission computing tomography are discussed in detail. Moreover, the further therapeutic treatments using multi-functional trackers endowed with photodynamic and photothermal modalities are also introduced to provide a comprehensive perspective in this promising research field.

引用

页码：1923 / 1947

页数：25

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