How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy?

被引:24
作者
Yuen, Eunice S. M. [1 ]
Sims, John R. [2 ]
机构
[1] Eli Lilly & Co, Windlesham GU20 6PH, Surrey, England
[2] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2014年 / 23卷 / 06期
关键词
Epilepsy; Photosensitive; Proof of principle; Drug development; PARTIAL-ONSET SEIZURES; BLIND CROSSOVER TRIAL; ADD-ON THERAPY; ANTIEPILEPTIC DRUG; PLACEBO; EFFICACY; CARISBAMATE; PROGABIDE; BRIVARACETAM; LORECLEZOLE;
D O I
10.1016/j.seizure.2014.03.011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: Human photosensitive epilepsy models have been used as proof of principle (POP) trials for epilepsy. Photosensitive patients, are exposed to intermittent photic stimulation and the reduction in sensitivity to the number of standard visual stimulation frequencies is used as an endpoint. The aim of this research was to quantify the predictive capabilities of photosensitive POP trials, through a survey of current literature. Methods: A literature search was undertaken to identify articles describing photosensitive POP trials. Minimally efficacious doses (MEDs) in epilepsy were compared to doses in the POP trials that produced 50-100% response (ED50-100). Ratios of these doses were calculated and summarised statistically. Results: The search identified ten articles describing a total of 17 anti-epileptic drugs. Of these, data for both MED and ED50-100 were available for 13 anti-epileptic drugs. The average ratio of MED to ED50-100 was 0.95(95% CI 0.60-1.30). The difference in MED to ED50-100 ratios between partial epilepsy (0.82) was not significantly different from that of generalised epilepsy (1.08) (p = 0.51). Conclusion: Photosensitive POP trials are a useful tool to quantitatively predict efficacy in epilepsy, and can be useful as early and informative indicators in anti-epileptic drug discovery and development. (C) 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:490 / 493
页数:4
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