Involvement of the Arp2/3 complex and WASP proteins in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages

被引：0

作者：

Krutetskaya, Z. I. ^{[1
]}

Milenina, L. S. ^{[1
]}

Naumova, A. A. ^{[1
]}

Butov, S. N. ^{[1
]}

Antonov, V. G. ^{[1
]}

Nozdrachev, A. D. ^{[1
]}

机构：

[1] St Petersburg State Univ, St Petersburg 199034, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 464卷 / 01期

关键词：

Actin Cytoskeleton; GSSG; External Medium; Thapsigargin; DOKLADY Biochemistry;

D O I：

10.1134/S1607672955050013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Fura-2AM fluorescent Ca2+ probe was used to study the possibility that the Arp2/3 complex and WASP proteins are involved in the effects of glutoxim and molixan on the intracellular Ca2+ concentration in macrophages. It has been demonstrated that preincubation of macrophages with inhibitors of the Arp2/3 complex or WASP proteins (CK-0944666 or wiskostatin, respectively) results in a significant suppression of Ca2+-responses induced by glutoxim or molixan. This suggests that polymerization of actin filaments is a process involved in the effect of glutoxim or molixan on intracellular Ca2+ concentration in macrophages.

引用

页码：279 / 282

页数：4

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