Incidence of syphilis seroconversion among HIV-infected persons in Asia: results from the TREAT Asia HIV Observational Database

被引：14

作者：

Ahn, Jin Young ^{[1
,2
,3
]}

Boettiger, David ^{[4
]}

Kiertiburanakul, Sasisopin ^{[5
]}

Merati, Tuti Parwati ^{[6
,7
]}

Huy, Bui Vu ^{[8
]}

Wong, Wing Wai ^{[9
]}

Ditangco, Rossana ^{[10
]}

Lee, Man Po ^{[11
]}

Oka, Shinichi ^{[12
]}

Durier, Nicolas ^{[13
]}

Choi, Jun Yong ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, 50 Yonsei Ro, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, AIDS Res Inst, 50 Yonsei Ro, Seoul 120752, South Korea

[3] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[4] UNSW Australia, Kirby Inst, Sydney, NSW, Australia

[5] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok, Thailand

[6] Udayana Univ, Fac Med, Bali, Indonesia

[7] Sanglah Hosp, Bali, Indonesia

[8] Natl Hosp Trop Dis, Hanoi, Vietnam

[9] Taipei Vet Gen Hosp, Taipei, Taiwan

[10] Res Inst Trop Med, Manila, Philippines

[11] Queen Elizabeth Hosp, Hong Kong, Hong Kong, Peoples R China

[12] Natl Ctr Global Hlth & Med, Tokyo, Japan

[13] Fdn AIDS Res, TREAT Asia, Bangkok, Thailand

来源：

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY | 2016年 / 19卷

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

syphilis; incidence; seroconversion; HIV; MSM; SEXUAL RISK BEHAVIOR; IMMUNODEFICIENCY-VIRUS-INFECTION; POSITIVE GAY MEN; CD4 CELL COUNTS; SAN-FRANCISCO; HOMOSEXUAL-MEN; TRANSMITTED INFECTIONS; ASYMPTOMATIC SYPHILIS; CHANGING PATTERNS; VIRAL LOAD;

D O I：

10.7448/IAS.19.1.20965

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p = 0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.

引用

页数：8

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