The c-FLIP-NH2 terminus (p22-FLIP) induces NF-κB activation

被引：159

作者：

Golks, Alexander ^{[1
]}

Brenner, Dirk ^{[1
]}

Krammer, Peter H. ^{[1
]}

Lavrik, Inna N. ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Immunogenet, Tumorimmunol Program, D-69120 Heidelberg, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 05期

关键词：

D O I：

10.1084/jem.20051556

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

c-FLIP proteins (isoforms: c-FLIPL, c-FLIPS, and c-FLIPR) play an essential role in the regulation of death receptor - induced apoptosis. Here, we demonstrate that the cytoplasmic NH2-terminal procaspase-8 cleavage product of c-FLIP (p22-FLIP) found in nonapoptotic malignant cells, primary T and B cells, and mature dendritic cells (DCs) strongly induces nuclear factor kappa B (NF-kappa B) activity by interacting with the I kappa B kinase (IKK) complex via the IKK gamma subunit. Thus, in addition to inhibiting apoptosis by binding to the death-inducing signaling complex, our data demonstrate a novel mechanism by which c-FLIP controls NF-kappa B activation and life/death decisions in lymphocytes and DCs.

引用

页码：1295 / 1305

页数：11

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