C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

被引：18

作者：

Hsieh, Chin-Lin

Tseng, Mei-Huims

Shao, Yi-Yuan

Chang, Jang-Yang

Kuo, Ching-Chuan

Chang, Chi-Yen

Kuo, Yueh-Hsiung ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Taipei Municipal Teachers Univ, Dept Sci Educ, Taipei 106, Taiwan

[3] Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 106, Taiwan

[4] Natl Hlth Res Inst, Inst Canc Res, Taipei 114, Taiwan

[5] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Med, Div Hematol Oncol, Taipei 114, Taiwan

[6] Acad Sinica, Inst BioAgr Sci, Taipei 115, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 11期

关键词：

D O I：

10.1021/np0600550

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C-35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C-35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 mu M.

引用

页码：1611 / 1613

页数：3

共 18 条

[11] SESQUITERPENOID GLYCOSIDES AND AN ACETOGENIN GLUCOSIDE FROM LESSINGIA-GLANDULIFERA
JOLAD, SD
TIMMERMANN, BN
HOFFMANN, JJ
BATES, RB
CAMOU, FA
SIAHAAN, TJ
[J]. PHYTOCHEMISTRY, 1988, 27 (07) : 2199 - 2204
[12] Kuo YH, 2003, CHEM PHARM BULL, V51, P986, DOI 10.1248/cpb.51.986
[13] Kuo YH, 2002, HELV CHIM ACTA, V85, P2657, DOI 10.1002/1522-2675(200209)85:9&lt
[14] 2657::AID-HLCA2657&gt
[15] 3.0.CO
[16] 2-B
[17] STUDIES ON EXTRACTIVE CONSTITUENTS OF BARK OF LIBOCEDRUS-FORMOSANA FLORIN .1. STRUCTURE OF 6ALPHA-HYDROXY-7-OXO-FERRUGINOL
KUO, YH
CHANG, BH
LIN, YT
[J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1975, 22 (01) : 49 - 52
[18] Tezuka Y, 1998, CHEM PHARM BULL, V46, P107, DOI 10.1248/cpb.46.107

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