GC-MS Profiling, Vibriocidal, Antioxidant, Antibiofilm, and Anti-Quorum Sensing Properties of Carum carvi L. Essential Oil: In Vitro and In Silico Approaches

被引:18
作者
Ghannay, Siwar [1 ]
Aouadi, Kaiss [1 ,2 ]
Kadri, Adel [3 ,4 ]
Snoussi, Mejdi [5 ,6 ]
机构
[1] Qassim Univ, Dept Chem, Coll Sci, Buraydah 51452, Saudi Arabia
[2] Univ Monastir, Fac Sci Monastir, Ave Environm, Monastir 5019, Tunisia
[3] Univ Sfax, Fac Sci Sfax, Dept Chem, BP1171, Sfax 3000, Tunisia
[4] Albaha Univ, Fac Sci & Arts Baljurashi, POB 1988, Albaha 65527, Saudi Arabia
[5] Hail Univ, Dept Biol, Coll Sci, POB 2440, Hail 2440, Saudi Arabia
[6] Univ Monastir, Higher Inst Biotechnol Monastir, Lab Genet Biodivers & Valorizat Bioresources LR11, Ave Tahar Haddad,BP74, Monastir 5000, Tunisia
来源
PLANTS-BASEL | 2022年 / 11卷 / 08期
关键词
volatile oil; Carum carvi L; antioxidant; Vibrio spp; biofilm; anti-quorum sensing; pharmacokinetics; molecular docking; CHEMICAL-COMPOSITION; RHIZOMA-POLYGONATI; EXTRACT; DOCKING; IDENTIFICATION; FOOD;
D O I
10.3390/plants11081072
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The main objectives of the present study were to investigate anti-Vibrio spp., antibiofilms, and anti-quorum-sensing (anti-QS) properties of caraway essential oil in relation to their phytochemical composition. The results obtained show the identification of twelve compounds, with carvone (58.2%) and limonene (38.5%) being the main ones. The obtained essential oil (EO) is particularly active against all Vibrio spp. species, with bacteriostatic action against all tested strains (MBC/MIC ratio >= 4) and with inhibition zones with high diameters of growth, ranging from 8.66 +/- 0.58 mm for V. furnisii ATCC 35016 to 37.33 +/- 0.58 mm for V. alginolyticus ATCC 17749. Caraway essential oil (Carvone/limonene chemotype) exhibits antioxidant activities by using four tests (DPPH = 15 +/- 0.23 mg/mL; reducing power = 7.8 +/- 0.01 mg/mL; beta-carotene = 3.9 +/- 0.025 mg/mL; chelating power = 6.8 +/- 0.05 mg/mL). This oil is particularly able to prevent cell-to-cell communication by inhibiting swarming motility, production of elastase and protease in Pseudomonas aeruginosa PAO1, and violacein production in C. violaceum in a concentration-dependent manner. A molecular docking approach shows good interaction of the identified bioactive molecules in caraway EO, with known target enzymes involved in antioxidant, antibacterial, and anti-QS activities having high binding energy. Overall, the obtained results highlight the possible use of caraway essential oil against pathogenic Vibrio species and to attenuate the secretion of virulence-related factors controlled by QS systems in Gram-negative bacteria. Therefore, this oil can be used by food industries to prevent biofilm formation on abiotic surfaces by Vibrio strains.
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页数:25
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共 69 条
  • [1] Ali A., 2020, Journal of Food Quality and Hazards Control, V7, P4, DOI 10.18502/jfqhc.7.1.2446
  • [2] RETRACTED: Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein (Retracted Article)
    Alminderej, Fahad
    Bakari, Sana
    Almundarij, Tariq, I
    Snoussi, Mejdi
    Aouadi, Kaiss
    Kadri, Adel
    [J]. PLANTS-BASEL, 2021, 10 (02): : 1 - 20
  • [3] Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies
    Alminderej, Fahad
    Bakari, Sana
    Almundarij, Tariq I.
    Snoussi, Mejdi
    Aouadi, Kaiss
    Kadri, Adel
    [J]. PLANTS-BASEL, 2020, 9 (11): : 1 - 18
  • [4] Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract
    Alreshidi, Mousa
    Noumi, Emira
    Bouslama, Lamjed
    Ceylan, Ozgur
    Veettil, Vajid N.
    Adnan, Mohd
    Danciu, Corina
    Elkahoui, Salem
    Badraoui, Riadh
    Al-Motair, Khalid A.
    Patel, Mitesh
    De Feo, Vincenzo
    Snoussi, Mejdi
    [J]. PLANTS-BASEL, 2020, 9 (11): : 1 - 20
  • [5] [Anonymous], 2010, European Pharmacopoeia, V1
  • [6] HPLC/MS Phytochemical Profiling with Antioxidant Activities of Echium humile Desf. Extracts: ADMET Prediction and Computational Study Targeting Human Peroxiredoxin 5 Receptor
    Aouadi, Kaiss
    Hajlaoui, Hafedh
    Arraouadi, Soumaya
    Ghannay, Siwar
    Snoussi, Mejdi
    Kadri, Adel
    [J]. AGRONOMY-BASEL, 2021, 11 (11):
  • [7] A Review on the Phytochemistry, Medicinal Properties and Pharmacological Activities of 15 Selected Myanmar Medicinal Plants
    Aye, Mya Mu
    Aung, Hnin Thanda
    Sein, Myint Myint
    Armijos, Chabaco
    [J]. MOLECULES, 2019, 24 (02):
  • [8] Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines
    Azam, Syed Sikander
    Abbasi, Sumra Wajid
    [J]. THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2013, 10
  • [9] Bacterial Quorum Sensing During Infection
    Azimi, Sheyda
    Klementiev, Alexander D.
    Whiteley, Marvin
    Diggle, Stephen P.
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020, 2020, 74 : 201 - 219
  • [10] Quorum Sensing Inhibitory and Anti-Biofilm Activity of Essential Oils and Their in vivo Efficacy in Food Systems
    Bai, Jamuna A.
    Vittal, Ravishankar Rai
    [J]. FOOD BIOTECHNOLOGY, 2014, 28 (03) : 269 - 292