Mycophenolate mofetil: a new immunosuppressive agent in dermatology and its potential indications

被引：12
作者：
Geilen, CC
Orfanos-Boeckel, H
Offermann, G
Orfanos, CE
机构：
[1] Free Univ Berlin, Klinikum Benjamin Franklin, Dermatol Klin & Poliklin, D-12200 Berlin, Germany
[2] Free Univ Berlin, Klinikum Benjamin Franklin, Med Klin Endokrinol & Nephrol 4, D-12200 Berlin, Germany
来源：
HAUTARZT | 2000年 / 51卷 / 02期
关键词：
mycophenolic acid; mycophenolate mofetil; immunsuppression; psoriasis; autoimmune dermatoses;
D O I：
10.1007/s001050050013
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mycophenolate mofetil represents a new immunosuppressive drug. Several case reports have shown that mycophenolate mofelil has a good therapeutic effect in patients with psoriasis and autoimmune dermatoses. Mycophenolate mofetil is a morpholine ester of mycophenolic acid which was shown in the 1970s to be effective in patients with severe psoriasis. Mycophenolate mofetil has an increased bioavailability as compared to mycophenolic acid and thereby an improved therapeutic window. Currently, mycophenolate mofetil is indiated for the prevention of organ rejection in transplant patients. The mode of action and the pharmacology of mycophenolate mofetil are reviewed and the current clinical experience with this immunosuppressive drug for dermatological disorders is summarized.
引用
收藏
页码：63 / 69
页数：7
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