Hepatitis E in High-Income Countries: What Do We Know? And What Are the Knowledge Gaps?

被引：27

作者：

Capai, Lisandru ^{[1
]}

Charrel, Remi ^{[2
]}

Falchi, Alessandra ^{[1
]}

机构：

[1] Univ Corse, INSERM, Lab Virol, BIOSCOPE EA7310, F-20250 Corte, France

[2] Aix Marseille Univ, UVE, INSERM 1207, IHU Mediterranee Infect,IRD 190, F-13005 Marseille, France

来源：

VIRUSES-BASEL | 2018年 / 10卷 / 06期

关键词：

Hepatitis E virus; clinical; transmission; zoonosis; virology; E VIRUS-INFECTION; NON-B-HEPATITIS; ENTERS LIVER-CELLS; TRANSMITTED NON-A; 1ST CASE-REPORT; RAW PORK LIVER; BLOOD-DONORS; GENOTYPE; VIRAL-HEPATITIS; ORF3; PROTEIN;

D O I：

10.3390/v10060285

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the fecal-oral route. HEV genotypes 1 and 2 infect only humans and cause mainly waterborne outbreaks. HEV genotypes 3 and 4 are widely represented in the animal kingdom, and are mainly transmitted as a zoonosis. For the past 20 years, HEV infection has been considered an imported disease in developed countries, but now there is evidence that HEV is an underrecognized pathogen in high-income countries, and that the incidence of confirmed cases has been steadily increasing over the last decade. In this review, we describe current knowledge about the molecular biology of HEV, its clinical features, its main routes of transmission, and possible therapeutic strategies in developed countries.

引用

页数：23