Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced reduction in cerebral blood flow

被引:6
作者
Lund, Anton [1 ]
Secher, Niels H. [2 ]
Hirasawa, Ai [3 ]
Ogoh, Shigehiko [4 ]
Hashimoto, Takeshi [5 ]
Schytz, Henrik W. [6 ]
Ashina, Messoud [6 ]
Sorensen, Henrik [2 ]
机构
[1] Univ Copenhagen, Rigshosp, Dept Neuroanaesthesia, DK-1168 Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Anaesthesia, Copenhagen Muscle Res Ctr, DK-1168 Copenhagen, Denmark
[3] Kyorin Univ, Sch Med, Emergency Dept, Mitaka, Tokyo 181, Japan
[4] Toyo Univ, Fac Sci & Engn, Dept Biomed Engn, Kawagoe, Saitama, Japan
[5] Ritsumeikan Univ, Grad Sch Sport & Hlth Sci, Kyoto, Shiga, Japan
[6] Univ Copenhagen, Rigshosp Glostrup, Dept Neurol, DK-1168 Copenhagen, Denmark
关键词
Cerebral oximetry; external carotid artery; internal carotid artery; monitoring; skin blood flow; skin oxygen saturation; OXYGEN-SATURATION; BYPASS; NIRS;
D O I
10.3109/00365513.2015.1101485
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction: Continuous non-invasive monitoring of cerebral blood flow (CBF) may be important during anaesthesia and several options are available. We evaluated the CerOx monitor that employs ultrasound tagged near infrared spectroscopy to estimate changes in a CBF index (CFI).Methods: Seven healthy males (age 21-26 years) hyperventilated and were administered phenylephrine to increase mean arterial pressure by 20-30mmHg. Frontal lobe tissue oxygenation (ScO2) and CFI were obtained using the CerOx and mean blood flow velocity in the middle cerebral artery (MCAv(mean)) was determined by transcranial Doppler. Blood flow in the internal and external carotid artery (ICAf and ECAf) was determined using duplex ultrasonography and forehead skin blood flow (SkBF) and oxygenation (SskinO2) by laser Doppler and white light spectroscopy.Results: During hyperventilation MCAv(mean) and ICAf decreased by 44% (median; interquartile range 40-49; p=0.016) and 46% (40-53; p=0.03), respectively. Conversely, CFI increased by 9% (2-31; p=0.016), while no significant change was observed in ScO2. SkBF increased by 19% (9-53; p=0.016) and SskinO2 by 6% (1-7; p=0.047), although ECAf was unchanged. Administration of phenylephrine was not associated with any changes in MCAv(mean), ICAf, ECAf, ScO2, SkBF, SskinO2, or CFI.Conclusion: The CerOx was able to detect a stable CBF during administration of phenylephrine. However, during hyperventilation MCAv(mean) and ICAf decreased while CFI increased, likely due to an increase in superficial tissue oxygenation. Thus, CFI does not provide an unbiased evaluation of changes in CBF.
引用
收藏
页码:82 / 87
页数:6
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