Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

被引：136
作者：
Cao, JQ
Wang, YX
Yu, JF
Xia, JY
Zhang, CF
Yin, DZ
Häfeli, UO
机构：
[1] Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China
[2] Cleveland Clin Fdn, Radiat Oncol Dept T28, Cleveland, OH 44195 USA
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2004年 / 277卷 / 1-2期
关键词：
magnetic nanoparticles; histidine; rhenium-188; tricarbonyl complex; radiolabeling;
D O I：
10.1016/j.jmmm.2003.10.022
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross.-linker. The magnetic nanoparticles were then radiolabeled with Re-188 with a labeling yield of 91.4 +/- 0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[Re-188(CO)(3)(H2O)(3)](+) core complexed with imidazolyl groups. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 174
页数：10
相关论文
共 32 条
  • [11] Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia
    Jordan, A
    Scholz, R
    Maier-Hauff, K
    Johannsen, M
    Wust, P
    Nadobny, J
    Schirra, H
    Schmidt, H
    Deger, S
    Loening, S
    Lanksch, W
    Felix, R
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) : 118 - 126
  • [12] Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain
    Kim, DK
    Zhang, Y
    Kehr, J
    Klason, T
    Bjelke, B
    Muhammed, M
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) : 256 - 261
  • [13] Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles
    Kim, DK
    Zhang, Y
    Voit, W
    Rao, KV
    Muhammed, M
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) : 30 - 36
  • [14] KIM DK, 2001, MAT RES SOC S P, V676
  • [15] Knapp FF, 1997, ANTICANCER RES, V17, P1783
  • [16] AMINO-SILANE MODIFIED SUPERPARAMAGNETIC PARTICLES WITH SURFACE-IMMOBILIZED ENZYME
    KOBAYASHI, H
    MATSUNAGA, T
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1991, 141 (02) : 505 - 511
  • [17] LEACH JH, 2003, THESIS STATE U BLACK
  • [18] Metzler-Nolte N, 2001, ANGEW CHEM INT EDIT, V40, P1040, DOI 10.1002/1521-3773(20010316)40:6<1040::AID-ANIE10400>3.0.CO
  • [19] 2-P
  • [20] IMMUNOSPECIFIC FERROMAGNETIC IRON-DEXTRAN REAGENTS FOR THE LABELING AND MAGNETIC SEPARATION OF CELLS
    MOLDAY, RS
    MACKENZIE, D
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1982, 52 (03) : 353 - 367
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