Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

被引：136
作者：
Cao, JQ
Wang, YX
Yu, JF
Xia, JY
Zhang, CF
Yin, DZ
Häfeli, UO
机构：
[1] Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China
[2] Cleveland Clin Fdn, Radiat Oncol Dept T28, Cleveland, OH 44195 USA
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2004年 / 277卷 / 1-2期
关键词：
magnetic nanoparticles; histidine; rhenium-188; tricarbonyl complex; radiolabeling;
D O I：
10.1016/j.jmmm.2003.10.022
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross.-linker. The magnetic nanoparticles were then radiolabeled with Re-188 with a labeling yield of 91.4 +/- 0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[Re-188(CO)(3)(H2O)(3)](+) core complexed with imidazolyl groups. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 174
页数：10
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