Molecular Mechanisms of Action of BPA

被引:274
|
作者
Acconcia, Filippo [1 ]
Pallottini, Valentina [1 ]
Marino, Maria [1 ,2 ]
机构
[1] Univ Rome Tre, Dept Sci, I-00146 Rome, Italy
[2] INBB Natl Lab Gender & Endocrine Disruptors, Rome, Italy
来源
DOSE-RESPONSE | 2015年 / 13卷 / 04期
关键词
bisphenol A; endocrine disruptors; low doses; nuclear receptors; signal transduction pathways; ENDOCRINE-DISRUPTING CHEMICALS; ESTROGEN-RECEPTOR-ALPHA; URINARY BISPHENOL-A; ARYL-HYDROCARBON RECEPTOR; CANCER-CELL-PROLIFERATION; ANDROGEN RECEPTOR; HUMAN HEALTH; ENVIRONMENTAL ESTROGENS; CONSENSUS STATEMENT; PLASMA-MEMBRANE;
D O I
10.1177/1559325815610582
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, nonhuman primates, and cell culture test systems. The BPA concentration derived from these experiments were used by government regulatory agencies to determine the safe exposure levels of BPA in humans. However, accumulating literature in vivo and in vitro indicate that at concentrations lower than that reported in toxicological studies, BPA could elicit a different endocrine-disrupting capacity. To further complicate this picture, BPA effects rely on several and diverse mechanisms that converge upon endocrine and reproductive systems. If all or just few of these mechanisms concur to the endocrine-disrupting potential of low doses of BPA is at present still unclear. Thus, taking into account that the incidence and/or prevalence of health problems associated with endocrine disruption have increased worldwide, the goal of the present review is to give an overview of the many mechanisms of BPA action in order to decipher whether different mechanisms are at the root of the effect of low dose of BPA on endocrine system.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms
    Sahu, Chittaranjan
    Jena, Gopabandhu
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (09) : 6685 - 6704
  • [42] Impact of Bisphenol A on the Cardiovascular System - Epidemiological and Experimental Evidence and Molecular Mechanisms
    Gao, Xiaoqian
    Wang, Hong-Sheng
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2014, 11 (08): : 8399 - 8413
  • [43] Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies
    Pinson, Anneline
    Franssen, Delphine
    Gerard, Arlette
    Parent, Anne-Simone
    Bourguignon, Jean-Pierre
    COMPTES RENDUS BIOLOGIES, 2017, 340 (9-10) : 432 - 438
  • [44] 18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms
    Bayav, Ibrahim
    Darendelioglu, Ekrem
    Caglayan, Cuneyt
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2024, 38 (02)
  • [45] Does bisphenol A (BPA) participates in the pathogenesis of Polycystic Ovary Syndrome (PCOS)?
    Urbanetz, Lorena Ana Mercedes Lara
    Soares Jr, Jose Maria
    Maciel, Gustavo Arantes Rosa
    Simoes, Ricardo dos Santos
    Baracat, Maria Candida Pinheiro
    Baracat, Edmund Chada
    CLINICS, 2023, 78
  • [46] Pubertal BPA exposure changes central ERα levels in female mice
    Yu, Cheng J.
    Fang, Qian Q.
    Tai, Fa D.
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2015, 40 (02) : 606 - 614
  • [47] Retinoids: mechanisms of action
    Berbis, P.
    ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2010, 137 : S97 - S103
  • [48] Mechanisms of Action of Dehydroepiandrosterone
    Clark, Barbara J.
    Prough, Russell A.
    Klinge, Carolyn M.
    DEHYDROEPIANDROSTERONE, 2018, 108 : 29 - 73
  • [49] The mechanisms of action of PPARs
    Berger, J
    Moller, DE
    ANNUAL REVIEW OF MEDICINE, 2002, 53 : 409 - 435
  • [50] Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets
    Bonofiglio, Daniela
    Giordano, Cinzia
    De Amicis, Francesca
    Lanzino, Marilena
    Ando, Sebastiano
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2016, 16 (08) : 596 - 604