Challenges for Drug Repurposing in the COVID-19 Pandemic Era

被引:95
作者
Sultana, Janet [1 ]
Crisafulli, Salvatore [1 ]
Gabbay, Flic [2 ]
Lynn, Elizabeth [3 ,4 ]
Shakir, Saad [3 ,4 ]
Trifiro, Gianluca [1 ]
机构
[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy
[2] TranScrip, Reading, Berks, England
[3] Drug Safety Res Unit, Southampton, Hants, England
[4] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England
关键词
drug repurposing; drug repositioning; COVID-19; pandemic; coronavirus; SYSTEM INHIBITORS; AZITHROMYCIN; MECHANISMS; SAFETY;
D O I
10.3389/fphar.2020.588654
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has led to a rush to repurpose existing drugs, although the underlying evidence base is of variable quality. The improving knowledge of the virology and clinical presentation of COVID-19 is leading to a broadening pool of potential pharmacological targets. The aim of this review is to describe regulatory and pharmacological aspects of drug repurposing and to identify drugs proposed for repurposing in COVID-19 based on registered clinical trials, discussing the evidence to support their use in the treatment of this disease. The challenges of the correct interpretation of existing pre-clinical/clinical evidence as well as the generation of new evidence concerning drug repurposing in COVID-19 will also be discussed.
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页数:13
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