Challenges for Drug Repurposing in the COVID-19 Pandemic Era

被引：94

作者：

Sultana, Janet ^{[1
]}

Crisafulli, Salvatore ^{[1
]}

Gabbay, Flic ^{[2
]}

Lynn, Elizabeth ^{[3
,4
]}

Shakir, Saad ^{[3
,4
]}

Trifiro, Gianluca ^{[1
]}

机构：

[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

[2] TranScrip, Reading, Berks, England

[3] Drug Safety Res Unit, Southampton, Hants, England

[4] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

drug repurposing; drug repositioning; COVID-19; pandemic; coronavirus; SYSTEM INHIBITORS; AZITHROMYCIN; MECHANISMS; SAFETY;

D O I：

10.3389/fphar.2020.588654

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has led to a rush to repurpose existing drugs, although the underlying evidence base is of variable quality. The improving knowledge of the virology and clinical presentation of COVID-19 is leading to a broadening pool of potential pharmacological targets. The aim of this review is to describe regulatory and pharmacological aspects of drug repurposing and to identify drugs proposed for repurposing in COVID-19 based on registered clinical trials, discussing the evidence to support their use in the treatment of this disease. The challenges of the correct interpretation of existing pre-clinical/clinical evidence as well as the generation of new evidence concerning drug repurposing in COVID-19 will also be discussed.

引用

页数：13

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