Challenges for Drug Repurposing in the COVID-19 Pandemic Era

被引：95

作者：

Sultana, Janet ^{[1
]}

Crisafulli, Salvatore ^{[1
]}

Gabbay, Flic ^{[2
]}

Lynn, Elizabeth ^{[3
,4
]}

Shakir, Saad ^{[3
,4
]}

Trifiro, Gianluca ^{[1
]}

机构：

[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

[2] TranScrip, Reading, Berks, England

[3] Drug Safety Res Unit, Southampton, Hants, England

[4] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

drug repurposing; drug repositioning; COVID-19; pandemic; coronavirus; SYSTEM INHIBITORS; AZITHROMYCIN; MECHANISMS; SAFETY;

D O I：

10.3389/fphar.2020.588654

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The coronavirus disease (COVID-19) pandemic has affected an estimated 16 million persons and caused 0.6 million deaths worldwide by September 2020. The pandemic has led to a rush to repurpose existing drugs, although the underlying evidence base is of variable quality. The improving knowledge of the virology and clinical presentation of COVID-19 is leading to a broadening pool of potential pharmacological targets. The aim of this review is to describe regulatory and pharmacological aspects of drug repurposing and to identify drugs proposed for repurposing in COVID-19 based on registered clinical trials, discussing the evidence to support their use in the treatment of this disease. The challenges of the correct interpretation of existing pre-clinical/clinical evidence as well as the generation of new evidence concerning drug repurposing in COVID-19 will also be discussed.

引用

页数：13

共 69 条

[1] The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study Rationale and Design [J].

Angus, Derek C. ;

Berry, Scott ;

Lewis, Roger J. ;

Al-Beidh, Farah ;

Arabi, Yaseen ;

van Bentum-Puijk, Wilma ;

Bhimani, Zahra ;

Bonten, Marc ;

Broglio, Kristine ;

Brunkhorst, Frank ;

Cheng, Allen C. ;

Chiche, Jean-Daniel ;

De Jong, Menno ;

Detry, Michelle ;

Goossens, Herman ;

Gordon, Anthony ;

Green, Cameron ;

Higgins, Alisa M. ;

Hullegie, Sebastiaan J. ;

Kruger, Peter ;

Lamontagne, Francois ;

Litton, Edward ;

Marshall, John ;

McGlothlin, Anna ;

McGuinness, Shay ;

Mouncey, Paul ;

Murthy, Srinivas ;

Nichol, Alistair ;

O'Neill, Genevieve K. ;

Parke, Rachael ;

Parker, Jane ;

Rohde, Gernot ;

Rowan, Kathryn ;

Turner, Anne ;

Young, Paul ;

Derde, Lennie ;

McArthur, Colin ;

Webb, Steven A. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2020, 17 (07) :879-891

[2] Optimizing the Trade-off Between Learning and Doing in a Pandemic [J].

Angus, Derek C. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (19) :1895-1896

[3] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice [J].

Bao, Linlin ;

Deng, Wei ;

Huang, Baoying ;

Gao, Hong ;

Liu, Jiangning ;

Ren, Lili ;

Wei, Qiang ;

Yu, Pin ;

Xu, Yanfeng ;

Qi, Feifei ;

Qu, Yajin ;

Li, Fengdi ;

Lv, Qi ;

Wang, Wenling ;

Xue, Jing ;

Gong, Shuran ;

Liu, Mingya ;

Wang, Guanpeng ;

Wang, Shunyi ;

Song, Zhiqi ;

Zhao, Linna ;

Liu, Peipei ;

Zhao, Li ;

Ye, Fei ;

Wang, Huijuan ;

Zhou, Weimin ;

Zhu, Na ;

Zhen, Wei ;

Yu, Haisheng ;

Zhang, Xiaojuan ;

Guo, Li ;

Chen, Lan ;

Wang, Conghui ;

Wang, Ying ;

Wang, Xinming ;

Xiao, Yan ;

Sun, Qiangming ;

Liu, Hongqi ;

Zhu, Fanli ;

Ma, Chunxia ;

Yan, Lingmei ;

Yang, Mengli ;

Han, Jun ;

Xu, Wenbo ;

Tan, Wenjie ;

Peng, Xiaozhong ;

Jin, Qi ;

Wu, Guizhen ;

Qin, Chuan .

NATURE, 2020, 583 (7818) :830-+

[4] Remdesivir for the Treatment of Covid-19-Final Report [J].

Beigel, John H. ;

Tomashek, Kay M. ;

Dodd, Lori E. ;

Mehta, Aneesh K. ;

Zingman, Barry S. ;

Kalil, Andre C. ;

Hohmann, Elizabeth ;

Chu, Helen Y. ;

Luetkemeyer, Annie ;

Kline, Susan ;

de Castilla, Diego Lopez ;

Finberg, Robert W. ;

Dierberg, Kerry ;

Tapson, Victor ;

Hsieh, Lanny ;

Patterson, Thomas F. ;

Paredes, Roger ;

Sweeney, Daniel A. ;

Short, William R. ;

Touloumi, Giota ;

Lye, David Chien ;

Ohmagari, Norio ;

Oh, Myoung-don ;

Ruiz-Palacios, Guillermo M. ;

Benfield, Thomas ;

Faetkenheuer, Gerd ;

Kortepeter, Mark G. ;

Atmar, Robert L. ;

Creech, C. Buddy ;

Lundgren, Jens ;

Babiker, Abdel G. ;

Pett, Sarah ;

Neaton, James D. ;

Burgess, Timothy H. ;

Bonnett, Tyler ;

Green, Michelle ;

Makowski, Mat ;

Osinusi, Anu ;

Nayak, Seema ;

Lane, H. Clifford .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) :1813-1826

[5] A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 [J].

Boulware, David R. ;

Pullen, Matthew F. ;

Bangdiwala, Ananta S. ;

Pastick, Katelyn A. ;

Lofgren, Sarah M. ;

Okafor, Elizabeth C. ;

Skipper, Caleb P. ;

Nascene, Alanna A. ;

Nicol, Melanie R. ;

Abassi, Mahsa ;

Engen, Nicole W. ;

Cheng, Matthew P. ;

LaBar, Derek ;

Lother, Sylvain A. ;

MacKenzie, Lauren J. ;

Drobot, Glen ;

Marten, Nicole ;

Zarychanski, Ryan ;

Kelly, Lauren E. ;

Schwartz, Ilan S. ;

McDonald, Emily G. ;

Rajasingham, Radha ;

Lee, Todd C. ;

Hullsiek, Kathy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (06) :517-525

[6] Labs rush to study coronavirus in transgenic animals — some are in short supply [J].

Ewen Callaway .

Nature, 2020, 579 (7798) :183-183

[7] Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study [J].

Campochiaro, Corrado ;

Della-Torre, Emanuel ;

Cavalli, Giulio ;

De Luca, Giacomo ;

Ripa, Marco ;

Boffini, Nicola ;

Tomelleri, Alessandro ;

Baldissera, Elena ;

Rovere-Querini, Patrizia ;

Ruggeri, Annalisa ;

Monti, Giacomo ;

De Cobelli, Francesco ;

Zangrillo, Alberto ;

Tresoldi, Moreno ;

Castagna, Antonella ;

Dagna, Lorenzo ;

Angelillo, Piera ;

Assanelli, Andrea ;

Calvisi, Stefania ;

Canetti, Diana ;

Cariddi, Adriana ;

Ciceri, Fabio ;

Della Torre, Emanuel ;

Farina, Nicola ;

Fazio, Maria ;

Landoni, Giovanni ;

Mancuso, Gaia ;

Marinosci, Alessandro ;

Oltolini, Chiara ;

Sartorelli, Silvia ;

Scarpellini, Paolo ;

Spessot, Marzia .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2020, 76 :43-49

[8] Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study [J].

Cavalli, Giulio ;

De Luca, Giacomo ;

Campochiaro, Corrado ;

Della-Torre, Emanuel ;

Ripa, Marco ;

Canetti, Diana ;

Oltolini, Chiara ;

Castiglioni, Barbara ;

Din, Chiara Tassan ;

Boffini, Nicola ;

Tomelleri, Alessandro ;

Farina, Nicola ;

Ruggeri, Annalisa ;

Rovere-Querini, Patrizia ;

Di Lucca, Giuseppe ;

Martinenghi, Sabina ;

Scotti, Raffaella ;

Tresoldi, Moreno ;

Ciceri, Fabio ;

Landoni, Giovanni ;

Zangrillo, Alberto ;

Scarpellini, Paolo ;

Dagna, Lorenzo .

LANCET RHEUMATOLOGY, 2020, 2 (06) :E325-E331

[9] COVID-19 and its implications for thrombosis and anticoagulation [J].

Connors, Jean M. ;

Levy, Jerrold H. .

BLOOD, 2020, 135 (23) :2033-2040

[10] Immunomodulatory indications of azithromycin in respiratory disease: a concise review for the clinician [J].

Cramer, Cassondra L. ;

Patterson, Allie ;

Alchakaki, Abdulrazak ;

Soubani, Ayman O. .

POSTGRADUATE MEDICINE, 2017, 129 (05) :493-499

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