Visfatin/Nampt induces telomere damage and senescence in human endothelial cells

被引：14

作者：

Villalobos, Laura A. ^{[1
,3
]}

Uryga, Anna ^{[2
]}

Romacho, Tania ^{[1
]}

Leivas, Alejandra ^{[1
]}

Sanchez-Ferrer, Carlos F. ^{[1
,3
]}

Erusalimsky, Jorge D. ^{[2
]}

Peiro, Concepcion ^{[1
,3
]}

机构：

[1] Univ Autonoma Madrid, Dept Farmacol & Terapeut, E-28049 Madrid, Spain

[2] Cardiff Metropolitan Univ, Sch Hlth Sci, Cardiff CF5 2YB, S Glam, Wales

[3] Hosp La Princesa, Inst Invest Sanitaria, Madrid, Spain

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2014年 / 175卷 / 03期

关键词：

Visfatin; Nampt; Endothelium; Senescence; DNA damage; Telomere; DNA-DAMAGE;

D O I：

10.1016/j.ijcard.2014.05.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：573 / 575

页数：3

共 11 条

[1] Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen [J].

Brodsky, SV ;

Gealekman, O ;

Chen, J ;

Zhang, F ;

Togashi, N ;

Crabtree, M ;

Gross, SS ;

Nasjletti, A ;

Goligorsky, MS .

CIRCULATION RESEARCH, 2004, 94 (03) :377-384

[2] SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence [J].

Cardus, Anna ;

Uryga, Anna K. ;

Walters, Gareth ;

Erusalimsky, Jorge D. .

CARDIOVASCULAR RESEARCH, 2013, 97 (03) :571-579

[3] Vascular endothelial senescence: from mechanisms to pathophysiology [J].

Erusalimsky, Jorge D. .

JOURNAL OF APPLIED PHYSIOLOGY, 2009, 106 (01) :326-332

[4]

Hasmann M, 2003, CANCER RES, V63, P7436

[5]

Kurz DJ, 2000, J CELL SCI, V113, P3613

[6] Defining vascular aging and cardiovascular risk [J].

Laurent, Stephane .

JOURNAL OF HYPERTENSION, 2012, 30 :S3-S8

[7] Visfatin/Nampt: An Adipokine with Cardiovascular Impact [J].

Romacho, Tania ;

Sanchez-Ferrer, Carlos F. ;

Peiro, Concepcion .

MEDIATORS OF INFLAMMATION, 2013, 2013

[8] Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness [J].

Scuteri, A ;

Najjar, SS ;

Muller, DC ;

Andres, R ;

Hougaku, H ;

Metter, EJ ;

Lakatta, EG .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (08) :1388-1395

[9] DNA damage foci at dysfunctional telomeres [J].

Takai, H ;

Smogorzewska, A ;

de Lange, T .

CURRENT BIOLOGY, 2003, 13 (17) :1549-1556

[10] Visfatin Impairs Endothelium-Dependent Relaxation in Rat and Human Mesenteric Microvessels through Nicotinamide Phosphoribosyltransferase Activity [J].

Vallejo, Susana ;

Romacho, Tania ;

Angulo, Javier ;

Villalobos, Laura A. ;

Cercas, Elena ;

Leivas, Alejandra ;

Bermejo, Elena ;

Carraro, Raffaele ;

Sanchez-Ferrer, Carlos F. ;

Peiro, Concepcion .

PLOS ONE, 2011, 6 (11)

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