Chemical glycobiology: why now?

被引：71

作者：

Seeberger, Peter H. ^{[1
,2
]}

机构：

[1] Inst Colloid & Interface, Dept Biomol Syst, Potsdam, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, D-1000 Berlin, Germany

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 06期

关键词：

OLIGOSACCHARIDES; CHEMISTRY;

D O I：

10.1038/nchembio0609-368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the structure and function of carbohydrates remains a key challenge for chemical biologists. Developments in carbohydrate synthesis and analysis together with the advent of high-throughput methods such as carbohydrate microarrays have helped shed light on the function of glycoconjugates. Similarly, consortia have provided technology platforms and focus to a burgeoning field. Now, recruitment of scientists from related fields and further integration of chemistry and biology to achieve technical goals are needed for rapid advancements.

引用

页码：368 / 372

页数：5

共 15 条

[1]

Boons G-J., 1998, Carbohydrate Chemistry

[2] GENE SYNTHESIS MACHINES - DNA CHEMISTRY AND ITS USES [J].

CARUTHERS, MH .

SCIENCE, 1985, 230 (4723) :281-285

[3] Glycoprotein structure determination mass spectrometry [J].

Dell, A ;

Morris, HR .

SCIENCE, 2001, 291 (5512) :2351-2356

[4]

Kunz H, 2002, ANGEW CHEM INT EDIT, V41, P4439, DOI 10.1002/1521-3773(20021202)41:23<4439::AID-ANIE4439>3.0.CO

[5]

2-6

[6] Glycosylation in cellular mechanisms of health and disease [J].

Ohtsubo, Kazuaki ;

Marth, Jamey D. .

CELL, 2006, 126 (05) :855-867

[7] Sweet spots in functional glycomics [J].

Paulson, JC ;

Blixt, O ;

Collins, BE .

NATURE CHEMICAL BIOLOGY, 2006, 2 (05) :238-248

[8] Automated solid-phase synthesis of oligosaccharides [J].

Plante, OJ ;

Palmacci, ER ;

Seeberger, PH .

SCIENCE, 2001, 291 (5508) :1523-1527

[9] NEW METHODS FOR THE SYNTHESIS OF GLYCOSIDES AND OLIGOSACCHARIDES - ARE THERE ALTERNATIVES TO THE KOENIGS-KNORR METHOD [J].

SCHMIDT, RR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (03) :212-235

[10] Toward automated synthesis of oligosaccharides and glycoproteins [J].

Sears, P ;

Wong, CH .

SCIENCE, 2001, 291 (5512) :2344-2350

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