Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer

被引：1
作者：
Krug, David [1 ,2 ]
Baumann, Rene [3 ]
Budach, Wilfried [4 ]
Dunst, Juergen [3 ]
Feyer, Petra [5 ]
Fietkau, Rainer [6 ]
Haase, Wulf [7 ]
Harms, Wolfgang [8 ]
Hehr, Thomas [9 ]
Piroth, Marc D. [10 ]
Sedlmayer, Felix [11 ]
Souchon, Rainer [12 ]
Wenz, Frederik [13 ]
Sauer, Rolf [6 ]
机构：
[1] Univ Hosp Heidelberg, Dept Radiat Oncol, Neuenheimer Feld 400, D-69120 Heidelberg, Germany
[2] Natl Ctr Radiat Res Oncol NCRO, Heidelberg Inst Radiat Oncol, Heidelberg, Germany
[3] Univ Hosp Schleswig Holstein, Kiel, Germany
[4] Heinrich Heine Univ, Dusseldorf, Germany
[5] Vivantes Hosp Neukoelln, Berlin, Germany
[6] Univ Hosp Erlangen, Erlangen, Germany
[7] St Vincentius Hosp, Karlsruhe, Germany
[8] St Clara Hosp, Basel, Switzerland
[9] Marienhosp Stuttgart, Dept Radiat Oncol, Stuttgart, Germany
[10] Witten Herdecke Univ, HELIOS Hosp Wuppertal, Wuppertal, Germany
[11] Paracelsus Med Univ Hosp, Salzburg, Austria
[12] Univ Hosp Tuebingen, Tubingen, Germany
[13] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, D-GRID77000 Mannheim, Germany
来源：
STRAHLENTHERAPIE UND ONKOLOGIE | 2018年 / 194卷 / 07期
关键词：
Local recurrence; Neoadjuvant therapy; Breast neoplasms; Radiotherapy; INTERNATIONAL EXPERT PANEL; DEGRO PRACTICAL GUIDELINES; SURGICAL ADJUVANT BREAST; TUMORS; 5; CM; STAGE-II; RADIATION-THERAPY; LOCOREGIONAL RECURRENCE; SYSTEMIC TREATMENT; LYMPH-NODES; MULTICENTER;
D O I：
10.1007/s00066-018-1270-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1(st) January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP BaEuro51/RTOG 1304 and Alliance A11202 are eagerly awaited.
引用
收藏
页码：607 / 618
页数：12
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