Hypoxia-Inducible Factor-1α C1772T Polymorphism and Cancer Risk: A Meta-Analysis Including 18,334 Subjects

被引：9
|
作者：
Ye, Yanwei [1 ,2 ]
Wang, Min [3 ]
Hu, Shuang [2 ,4 ]
Shi, Yingqiang [5 ,6 ]
Zhang, Xiefu [1 ,2 ]
Zhou, Ye [5 ,6 ]
Zhao, Chunlin [1 ,2 ]
Wang, Guojun [1 ,2 ]
Wen, Jianguo [2 ]
Zong, Hong [2 ,4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Inst Clin Med, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 5, Dept Funct, Zhengzhou, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Peoples R China
[5] Fudan Univ, Shanghai Canc Ctr, Dept Stomach & Soft Tissue Sarcoma Surg, Shanghai 200433, Peoples R China
[6] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China
来源：
CANCER INVESTIGATION | 2014年 / 32卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Hypoxia-inducible factor-1 alpha; HIF-1; alpha; Polymorphism; C1772T; Meta analysis; SINGLE NUCLEOTIDE POLYMORPHISMS; FACTOR-I; PROSTATE-CANCER; FACTOR; 1-ALPHA; HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA GENE; CONFER SUSCEPTIBILITY; HIF-1-ALPHA GENE; BREAST; GROWTH; EXPRESSION;
D O I：
10.3109/07357907.2014.883527
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Studies on HIF 1 alpha C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting. We conducted a meta-analysis utilizing 29 eligible case-control studies to analyze the data concerning the association between the HIF-1 alpha C1772T polymorphism and cancer risks. There was statistical association between the HIF-1 alpha CT/TT genotype and cancer risk (OR= 1.28, 95% CI= 1.06- 1.54, P-heterogeneity < .00001). The stability of these observations was confirmed by a one-way sensitivity analysis. Our findings suggested that CT/TT genotype was associated with increased risks of prostate cancer. Besides, the HIF-1 alpha C1772T polymorphism most likely contributes to susceptibility to malignant tumors, especially in American population.
引用
收藏
页码：126 / 135
页数：10
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