Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide

被引：31

作者：

Saifullah, Bullo ^{[1
]}

Arulselvan, Palanisamy ^{[2
]}

El, Mohamed Ezzat Zowalaty ^{[3
]}

Fakurazi, Harida ^{[2
,4
]}

Webster, Thomas J. ^{[2
,5
,6
,7
]}

Geilich, Benjamin M. ^{[5
,6
]}

Hussein, Mohd Zobir ^{[1
]}

机构：

[1] Univ Putra Malaysia, Inst Adv Technol, Mat Synth & Characterizat Lab, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Lab Vaccines & Immunotherapeut, Serdang 43400, Selangor, Malaysia

[3] Jazan Univ, Fac Publ Hlth & Trop Med, Dept Environm Hlth, Jazan, Saudi Arabia

[4] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Selangor, Malaysia

[5] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[6] Northeastern Univ, Bioengn Program, Boston, MA 02115 USA

[7] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21413, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2014年 / 9卷

关键词：

tuberculosis; isoniazid; Mg/Al LDH; nanodelivery system; GROWTH INDICATOR TUBE; MYCOBACTERIUM-TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; IN-VITRO; HEPATOTOXICITY; RIFAMPIN; SUSCEPTIBILITY; NANOPARTICLES; PYRAZINAMIDE;

D O I：

10.2147/IJN.S63608

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB.

引用

页码：4749 / 4762

页数：14

共 43 条

[21] Inorganic Metal Hydroxide Nanoparticles for Targeted Cellular Uptake Through Clathrin-Mediated Endocytosis [J].