Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide

被引:31
作者
Saifullah, Bullo [1 ]
Arulselvan, Palanisamy [2 ]
El, Mohamed Ezzat Zowalaty [3 ]
Fakurazi, Harida [2 ,4 ]
Webster, Thomas J. [2 ,5 ,6 ,7 ]
Geilich, Benjamin M. [5 ,6 ]
Hussein, Mohd Zobir [1 ]
机构
[1] Univ Putra Malaysia, Inst Adv Technol, Mat Synth & Characterizat Lab, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Inst Biosci, Lab Vaccines & Immunotherapeut, Serdang 43400, Selangor, Malaysia
[3] Jazan Univ, Fac Publ Hlth & Trop Med, Dept Environm Hlth, Jazan, Saudi Arabia
[4] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Selangor, Malaysia
[5] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
[6] Northeastern Univ, Bioengn Program, Boston, MA 02115 USA
[7] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21413, Saudi Arabia
关键词
tuberculosis; isoniazid; Mg/Al LDH; nanodelivery system; GROWTH INDICATOR TUBE; MYCOBACTERIUM-TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; IN-VITRO; HEPATOTOXICITY; RIFAMPIN; SUSCEPTIBILITY; NANOPARTICLES; PYRAZINAMIDE;
D O I
10.2147/IJN.S63608
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB.
引用
收藏
页码:4749 / 4762
页数:14
相关论文
共 43 条
[1]   FT-IR and FT-Raman spectroscopic studies of adsorption of isoniazid by montmorillonite and saponite [J].
Akyuz, Sevim ;
Akyuz, Tanil .
VIBRATIONAL SPECTROSCOPY, 2008, 48 (02) :229-232
[2]   Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme [J].
Al Ali, Samer Hasan Hussein ;
Al-Qubaisi, Mothanna ;
Hussein, Mohd Zobir ;
Ismail, Maznah ;
Zainal, Zulkarnain ;
Hakim, Muhammad Nazrul .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :4251-4262
[3]  
[Anonymous], GLOB TUB REP 2013
[4]   Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite [J].
Barahuie, Farahnaz ;
Hussein, Mohd Zobir ;
Hussein-Al-Ali, Samer Hasan ;
Arulselvan, Palanisamy ;
Fakurazi, Sharida ;
Zainal, Zulkarnain .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2013, 8 :1975-1987
[5]   HYDROTALCITE-TYPE ANIONIC CLAYS: PREPARATION, PROPERTIES AND APPLICATIONS [J].
Cavani, F. ;
Trifiro, F. ;
Vaccari, A. .
CATALYSIS TODAY, 1991, 11 (02) :173-301
[6]   Facile synthesis of a novel magnetic core-shell hierarchical composite submicrospheres Fe3O4@CuNiAl-LDH under ambient conditions [J].
Chen, Xitao ;
Mi, Fei ;
Zhang, Hui ;
Zhang, Huaiqian .
MATERIALS LETTERS, 2012, 69 :48-51
[7]   Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles [J].
Clemens, Daniel L. ;
Lee, Bai-Yu ;
Xue, Min ;
Thomas, Courtney R. ;
Meng, Huan ;
Ferris, Daniel ;
Nel, Andre E. ;
Zink, Jeffrey I. ;
Horwitz, Marcus A. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) :2535-2545
[8]   Thermal decomposition of ammonia.: N2H4 -: an intermediate reaction product [J].
Dirtu, Daniela ;
Odochian, Lucia ;
Pui, Aurel ;
Humelnicu, Ionel .
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 2006, 4 (04) :666-673
[9]   Applications of layered double hydroxides [J].
Feng, L ;
Duan, X .
LAYERED DOUBLE HYDROXIDES, 2006, 119 :193-223
[10]   Chemical degradation of liposomes by serum components detected by NMR [J].
Foradada, M ;
Pujol, MD ;
Bermúdez, J ;
Estelrich, J .
CHEMISTRY AND PHYSICS OF LIPIDS, 2000, 104 (02) :133-148