Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement

被引：83

作者：

Polyzos, Stergios A. ^{[1
]}

Perakakis, Nikolaos ^{[2
]}

Mantzoros, Christos S. ^{[2
,3
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Pharmacol 1, Fac Med, Thessaloniki 54124, Macedonia, Greece

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Internal Med, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston VA Healthcare Syst, Sect Endocrinol, Boston, MA 02115 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2019年 / 96卷

关键词：

Acquired lipodystrophy; Acquired partial lipodystrophy; Congenital lipodystrophy; Familial partial lipodystrophy; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; FAMILIAL PARTIAL LIPODYSTROPHY; ACQUIRED GENERALIZED LIPODYSTROPHY; HAART-ASSOCIATED LIPODYSTROPHY; REVERSES INSULIN-RESISTANCE; SEIP CONGENITAL LIPODYSTROPHY; HIV-INFECTED PATIENTS; BETA-CELL FUNCTION; P465L PPAR-GAMMA; ADIPOSE-TISSUE; HEPATIC STEATOSIS;

D O I：

10.1016/j.metabol.2019.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders characterized by complete or partial absence of subcutaneous adipose tissue that may occur simultaneously with the pathological, ectopic, accumulation of fat in other regions of the body, including the liver. Fatty liver adds significantly to hepatic and extra-hepatic morbidity in patients with lipodystrophy. Lipodystrophy is strongly associated with severe insulin resistance and related comorbidities, such as hyperglycemia, hyperlipidemia and nonalcoholic fatty liver disease (NAFID), but other hepatic diseases may co-exist in some types of lipodystrophy, including autoimmune hepatitis in acquired lipodystrophies, or viral hepatitis in human immunodeficiency virus (HIV)-associated lipodystrophy. The aim of this review is to summarize evidence linking lipodystrophy with hepatic disease and to provide a special focus on potential therapeutic perspectives of leptin replacement therapy and adiponectin upregulation in lipodystrophy. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：66 / 82

页数：17

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