Serum Antibody Response to Matrix Protein 2 Following Natural Infection With 2009 Pandemic Influenza A(H1N1) Virus in Humans

被引：43
|
作者：
Zhong, Weimin [1 ]
Reed, Carrie [1 ]
Blair, Patrick J. [2 ]
Katz, Jacqueline M. [1 ]
Hancock, Kathy [1 ]
机构：
[1] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA
[2] Naval Hlth Res Ctr, San Diego, CA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 07期
关键词：
Influenza A virus; Matrix protein 2; Antibody; Human; H1N1; INFLUENZA; M2; PROTEIN; MONOCLONAL-ANTIBODY; EXTRACELLULAR DOMAIN; CROSS-PROTECTION; A H1N1; VACCINATION; ECTODOMAIN; HEMAGGLUTININ; M2-PROTEIN;
D O I：
10.1093/infdis/jit811
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural infection-induced humoral immunity to matrix protein 2 (M2) of influenza A viruses in humans is not fully understood. Evidence suggests that anti-M2 antibody responses following influenza A virus infection are weak and/or transient. We show that the seroprevalence of anti-M2 antibodies increased with age in 317 serum samples from healthy individuals in the United States in 2007-2008. Infection with 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) elicited a recall serum antibody response to M2 protein of A(H1N1)pdm09 in 47% of the affected 118 individuals tested. Anti-M2 antibody responses were more robust among individuals with preexisting antibodies to M2 protein. Moreover, the antibodies induced as a result of infection with A(H1N1)pdm09 were cross-reactive with M2 protein of seasonal influenza A viruses. These results emphasize the need to further investigate the possible roles of anti-M2 antibodies in human influenza A virus infection.
引用
收藏
页码：986 / 994
页数：9
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