Selective Diacetoxylation of Disubstituted 1,2,3-Triazoles through Palladium-Catalyzed C-H Activation

被引：6

作者：

Yang, Jianhua ^{[1
]}

Zhao, Fen ^{[1
]}

Liu, Yaowen ^{[1
]}

Luo, Fang ^{[1
]}

Cheng, Huiling ^{[1
]}

Jiang, Yubo ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Sci, Jingming South Rd 727, Kunming 650500, Yunnan, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 10期

基金：

中国国家自然科学基金;

关键词：

palladium catalysis; regioselectivity; acetoxylation; diacetoxytriazoles; C-H activation; CLICK CHEMISTRY; DIRECTING GROUP; 1,3-DIPOLAR CYCLOADDITION; MEDICINAL CHEMISTRY; ARYLATION SEQUENCE; COUPLING REACTIONS; BOND FORMATION; FUNCTIONALIZATION; ARENES; ACETOXYLATION;

D O I：

10.1055/s-0036-1591564

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient selective diacetoxylation of 1,4-disubstituted 1,2,3-triazoles by Pd-catalyzed C-H bond activation is described. PhI(OAc)(2) was used as an acetyloxy source to convert aromatic sp(2)C-H bonds into C-O bonds with high selectivity by employing a 1,2,3-triazole ring as an elegant directing group. A range of 1,2,3-triazoles bearing two acetyloxy groups can be readily synthesized by the reaction.

引用

页码：1373 / 1378

页数：6

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