Catalyst and Additive-Free Direct Amidation/Halogenation of Tertiary Arylamines with N-haloimide/amides

被引：9

作者：

Xu, Xiu-Juan ^{[1
]}

Amuti, Adila ^{[1
]}

Wusiman, Abudureheman ^{[1
,2
]}

机构：

[1] Xinjiang Normal Univ, Sch Chem & Chem Engn, Urumqi 830054, Peoples R China

[2] Xinjiang Key Lab Energy Storage & Photoelectrocat, Urumqi 830054, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 22期

基金：

中国国家自然科学基金;

关键词：

catalyst-free; C-H activation; tertiary amines; amidation; N-haloimide; H BOND ADJACENT; METAL-FREE; HYPERVALENT IODINE(III); NATURAL-PRODUCTS; INTERMOLECULAR AMINATION; C(SP(3))-H AMIDATION; COUPLING REACTIONS; EFFICIENT ACCESS; MANNICH BASES; FUNCTIONALIZATION;

D O I：

10.1002/adsc.202000796

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An approach has been developed for the amidation (halogenation) of tertiary arylamines by electrophilic activation usingN-haloimide/amides. Several control experiments have been performed, and the coupling reaction outcomes indicated that theN-haloimide/amide brings three major functions, including electrophilic activation, aromatic halogenation and nucleophilic nitrogen sources. This cascade reaction features simple manipulation, requires no additional catalyst, oxidant or additives, and is performed under mild conditions.

引用

页码：5002 / 5008

页数：7