An update on therapeutic drug monitoring for antiretroviral drugs

被引:66
|
作者
Back, David [1 ]
Gibbons, Sara [1 ]
Khoo, Saye [1 ]
机构
[1] Univ Liverpool, Pharmacol Res Labs, Liverpool L69 3GF, Merseyside, England
关键词
therapeutic drug monitoring; inhibitory quotients; patient outcome; randomized controlled trials; consensus statements;
D O I
10.1097/01.ftd.0000211825.57984.41
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
There is an increasing uptake of TDM of antiretroviral drugs, particularly in Europe. There is consensus that current antiretroviral drugs meet most of the criteria of drugs that can be considered as candidates for a TDM strategy. This review examines the pharmacokinetic-pharmacodynamic relationship for protease inibitors and non nucleoside reverse transcriptase inhibitor, give an overview of the published randomised clinical trials and then summarises the scenarios for use of TDM. Finally the development of the inhibitory quotient (IQ) concept is discussed.
引用
收藏
页码:468 / 473
页数:6
相关论文
共 50 条
  • [41] Immunosuppressant drugs - the role of therapeutic drug monitoring
    Johnston, A
    Holt, DW
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 52 : 61S - 73S
  • [42] Therapeutic drug monitoring of antimetabolic cytotoxic drugs
    Lennard, L
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 47 (02) : 131 - 143
  • [43] THERAPEUTIC DRUG-MONITORING (IMMUNOSUPPRESSIVE DRUGS)
    CHOU, D
    ANALYTICAL CHEMISTRY, 1993, 65 (12) : R412 - R415
  • [44] Evaluation of therapeutic drug monitoring of antiepileptic drugs
    Irshaid, YM
    Hamdi, AA
    Al Homrany, M
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2003, 41 (03) : 126 - 131
  • [45] Therapeutic drug monitoring of the newer antiepileptic drugs
    Johannessen, SI
    Battino, D
    Berry, DJ
    Bialer, M
    Krämer, G
    Tomson, T
    Patsalos, PN
    THERAPEUTIC DRUG MONITORING, 2003, 25 (03) : 347 - 363
  • [46] Therapeutic drug monitoring of newer antiepileptic drugs
    Brandt, Christian
    May, Theodor W.
    LABORATORIUMSMEDIZIN-JOURNAL OF LABORATORY MEDICINE, 2011, 35 (03): : 161 - 169
  • [47] A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
    Mohammadpour, Niloufar
    Elyasi, Sepideh
    Vahdati, Naser
    Mohammadpour, Amir Hooshang
    Shamsara, Jamal
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2011, 14 (06) : 485 - 498
  • [48] Therapeutic drug monitoring of atypical antipsychotic drugs
    Grundmann, Milan
    Kacirova, Ivana
    Urinovska, Romana
    ACTA PHARMACEUTICA, 2014, 64 (04) : 387 - 401
  • [49] The current role of liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressant and antiretroviral drugs
    Taylor, Paul J.
    Tai, Chun-Hui
    Franklin, Michael E.
    Pillans, Peter I.
    CLINICAL BIOCHEMISTRY, 2011, 44 (01) : 14 - 20
  • [50] Therapeutic Drug Monitoring: Role for a Pharmacist in Multidisciplinary Antiretroviral Management
    Slish, Judianne C.
    Catanzaro, Linda M.
    Okusanya, Olanrewaju
    Demeter, Lisa M.
    Albrecht, Mary
    DiFrancesco, Robin
    Morse, Gene D.
    JOURNAL OF PHARMACY PRACTICE, 2005, 18 (04) : 310 - 321