An update on therapeutic drug monitoring for antiretroviral drugs

被引：66
|
作者：
Back, David [1 ]
Gibbons, Sara [1 ]
Khoo, Saye [1 ]
机构：
[1] Univ Liverpool, Pharmacol Res Labs, Liverpool L69 3GF, Merseyside, England
来源：
THERAPEUTIC DRUG MONITORING | 2006年 / 28卷 / 03期
关键词：
therapeutic drug monitoring; inhibitory quotients; patient outcome; randomized controlled trials; consensus statements;
D O I：
10.1097/01.ftd.0000211825.57984.41
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
There is an increasing uptake of TDM of antiretroviral drugs, particularly in Europe. There is consensus that current antiretroviral drugs meet most of the criteria of drugs that can be considered as candidates for a TDM strategy. This review examines the pharmacokinetic-pharmacodynamic relationship for protease inibitors and non nucleoside reverse transcriptase inhibitor, give an overview of the published randomised clinical trials and then summarises the scenarios for use of TDM. Finally the development of the inhibitory quotient (IQ) concept is discussed.
引用
收藏
页码：468 / 473
页数：6
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